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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

15,213 questions in 2,394 reviews

current versions
No studies 15,213 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Dalteparin vs placebo
Number of other sickle‐related events ‐ not measured · patients with people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Dalteparin vs placebo
Quality of life (e.g. absence from school, lost time at work, mobility) as assessed by any validated questionnaire either generic or SCD specific) ‐ not measured · patients with people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Dalteparin vs placebo
Hospitalisation (number and duration) ‐ not measured · patients with people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Dalteparin vs placebo
Participant satisfaction with the medication assessed by any appropriate and validated questionnaire (either generic or SCD specific) ‐ not measured · patients with people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Dalteparin vs placebo
Adverse events associated with the use of anticoagulants (e.g. bleeding) ‐ not measured · patients with people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Tinzaparin vs placebo
Number of serious complications of SCD ‐ not measured · people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Tinzaparin vs placebo
Number of other sickle‐related events ‐ not measured · people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Tinzaparin vs placebo
Quality of life (e.g. absence from school, lost time at work, mobility) as assessed by any validated questionnaire either generic or SCD specific) ‐ not measured · people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Tinzaparin vs placebo
Participant satisfaction with the medication assessed by any appropriate and validated questionnaire (either generic or SCD specific) ‐ not measured · people with sickle cell disease
Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Severe adverse events or withdrawals (due to adverse events) ‐ not reported · People with hip or knee osteoarthritis
High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse event · participants with CHD after PCI
Tong‐xin‐luo capsule for patients with coronary heart disease after percutaneous coronary intervention (2015) · Cochrane
no estimate extractedNRNo studies
Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract
Neurodevelopmental outcome at approximately two years’ corrected age · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract
Death or oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract
Pneumothorax · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract
Pulmonary hemorrhage · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract
Neurodevelopmental outcome at approximately two years’ corrected age · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract
Neurodevelopmental outcome at approximately two years’ corrected age · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant
Oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant
Death or oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant
Pulmonary hemorrhage · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant
Severe intraventricular hemorrhage in infants who received neuroimaging · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Modified bovine minced lung surfactant extract vs porcine lung lavage surfactant
Neurodevelopmental outcome at approximately two years corrected age · Preterm infants for treatment of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract
Neurodevelopmental outcome at approximately two years’ corrected age · Preterm infants for prevention of RDS
Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events · participants with low back pain
Pilates for low back pain (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events · patients with low back pain
Pilates for low back pain (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · patients undergoing orthognathic surgery
Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Systemic infection · patients undergoing orthognathic surgery
Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events · patients undergoing orthognathic surgery
Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Duration of hospital stay · patients undergoing orthognathic surgery
Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · patients undergoing orthognathic surgery
Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Systemic infection · patients undergoing orthognathic surgery
Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery (2015) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Duration of hospital stay · patients undergoing orthognathic surgery
Antibiotic prophylaxis for preventing infectious complications in orthognathic surgery (2015) · Cochrane
no estimate extractedNRNo studies
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg
Participant‐reported improvement of hirsutism ‐ not measured · patients with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg
Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg
Change in health‐related quality of life (HRQOL) ‐ not measured · patients with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg
Change in BMI ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg
Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Spironolactone 100 mg vs placebo
Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Spironolactone 100 mg vs placebo
Change in BMI ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Spironolactone 100 mg vs placebo
Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Finasteride 5 mg to 7.5 mg vs placebo
Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Finasteride 5 mg to 7.5 mg vs placebo
Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Metformin 500 mg to 2550 mg per day vs placebo
Participant‐reported improvement of hirsutism ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Metformin 500 mg to 2550 mg per day vs placebo
Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Metformin 500 mg to 2550 mg per day vs placebo
Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Finasteride 5 mg vs spironolactone 100 mg
Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Finasteride 5 mg vs spironolactone 100 mg
Change in BMI ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Finasteride 5 mg vs spironolactone 100 mg
Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day
Participant‐reported improvement of hirsutism ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day
Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism
Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane
no estimate extractedNRNo studies