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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

726 questions in 98 reviews · Pregnancy and Childbirth

current versions
No studies 726 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course
Breastfeeding at hospital discharge ‐ not reported · the woman
Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health… (2022) · Cochrane
no estimate extractedNRNo studies
Dexamethasone vs betamethasone – maternal outcomes
Death · women at risk of preterm birth
Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm… (2022) · Cochrane
no estimate extractedNRNo studies
Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes
Chronic lung disease · women at risk of preterm birth
Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm… (2022) · Cochrane
no estimate extractedNRNo studies
Betamethasone acetate plus phosphate vs betamethasone phosphate – fetal/neonatal outcomes
Necrotising enterocolitis · women at risk of preterm birth
Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm… (2022) · Cochrane
no estimate extractedNRNo studies
Betamethasone acetate plus phosphate vs betamethasone phosphate – fetal/neonatal outcomes
Chronic lung disease · women at risk of preterm birth
Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm… (2022) · Cochrane
no estimate extractedNRNo studies
Dexamethasone vs betamethasone – maternal outcomes
Puerperal sepsis · women at risk of preterm birth
Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine ultrasound
Positive birth experience (primary outcome)№ of participants: (0 studies) · pregnant women, multiparous, in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine rectal examination
Chorioamnionitis (primary outcome)№ of participants: (0 studies) · pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine rectal examination
Maternal pain (primary outcome)№ of participants: (0 RCTs) · pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine 4‐hourly vaginal examinations vs routine 2‐hourly vaginal examinations
Positive birth experience (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine 4‐hourly vaginal examinations vs routine 2‐hourly vaginal examinations
Chorioamnionitis (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine 4‐hourly vaginal examinations vs routine 2‐hourly vaginal examinations
Neonatal infection (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine ultrasound
Augmentation of labour (primary outcome)№ of participants: (0 studies) · pregnant women, multiparous, in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine 4‐hourly vaginal examinations vs routine 2‐hourly vaginal examinations
Admission to NICU (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine 4‐hourly vaginal examinations vs routine 2‐hourly vaginal examinations
Maternal pain (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examinations vs vaginal examinations
Positive birth experience (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examinations vs vaginal examinations
Maternal pain (primary outcome)№ of participants: (0 studies) · primiparous pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine ultrasound
Spontaneous vaginal birth (primary outcome)№ of participants: (0 studies) · pregnant women, multiparous, in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine ultrasound
Chorioamnionitis (primary outcome)№ of participants: (0 studies) · pregnant women, multiparous, in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine ultrasound
Neonatal infection (primary outcome)№ of participants: (0 studies) · pregnant women, multiparous, in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine ultrasound
Admission to NICU (primary outcome)№ of participants: (0 studies) · pregnant women, multiparous, in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Routine vaginal examination vs routine rectal examination
Women's positive experiences№ of participants: (0 studies) · pregnant women in labour at term
Routine vaginal examinations compared to other methods for assessing progress of labour to improve outcomes… (2022) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Remifentanil vs diazepam
Perinatal mortality · health problem or population
Perioperative pharmacological interventions for fetal immobilisation during fetal surgery and invasive… (2022) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Remifentanil vs diazepam
Time taken to perform procedure · health problem or population
Perioperative pharmacological interventions for fetal immobilisation during fetal surgery and invasive… (2022) · Cochrane
no estimate extractedNRNo studies
Cervical pessary vs vaginal progesterone
Birthweight · women with singleton pregnancies at risk of cervical insufficiency
Cervical pessary for preventing preterm birth in singleton pregnancies (2022) · Cochrane
no estimate extractedNRNo studies
Cervical pessary vs cervical cerclage
Neonatal/paediatric care unit admission · women with singleton pregnancies at risk of cervical insufficiency
Cervical pessary for preventing preterm birth in singleton pregnancies (2022) · Cochrane
no estimate extractedNRNo studies
Cervical pessary vs cervical cerclage
Birthweight · women with singleton pregnancies at risk of cervical insufficiency
Cervical pessary for preventing preterm birth in singleton pregnancies (2022) · Cochrane
no estimate extractedNRNo studies
Cervical pessary vs no treatment
Harm to offspring from the intervention · women with singleton pregnancies at risk of cervical insufficiency
Cervical pessary for preventing preterm birth in singleton pregnancies (2022) · Cochrane
no estimate extractedNRNo studies
Cervical pessary vs no treatment
Birthweight · women with singleton pregnancies at risk of cervical insufficiency
Cervical pessary for preventing preterm birth in singleton pregnancies (2022) · Cochrane
no estimate extractedNRNo studies
Lateral postures vs other postures
Neonatal encephalopathy (as defined by trialists · fetal malposition in labour
Maternal postures for fetal malposition in labour for improving the health of mothers and their infants (2022) · Cochrane
no estimate extractedNRNo studies
Lateral postures vs other postures
Need for respiratory support · fetal malposition in labour
Maternal postures for fetal malposition in labour for improving the health of mothers and their infants (2022) · Cochrane
no estimate extractedNRNo studies
Lateral postures vs other postures
Neonatal jaundice requiring phototherapy · fetal malposition in labour
Maternal postures for fetal malposition in labour for improving the health of mothers and their infants (2022) · Cochrane
no estimate extractedNRNo studies
Oxytocin solution vs plasma expander
Maternal mortality · management of retained placenta
Umbilical vein injection for management of retained placenta (2021) · Cochrane
no estimate extractedNRNo studies
Oxytocin solution vs plasma expander
Blood transfusion · management of retained placenta
Umbilical vein injection for management of retained placenta (2021) · Cochrane
no estimate extractedNRNo studies
Oxytocin solution vs plasma expander
Additional therapeutic uterotonics · management of retained placenta
Umbilical vein injection for management of retained placenta (2021) · Cochrane
no estimate extractedNRNo studies
Oxytocin solution vs plasma expander
Need for treatment with antibiotics (infection) · management of retained placenta
Umbilical vein injection for management of retained placenta (2021) · Cochrane
no estimate extractedNRNo studies
Oxytocin solution vs plasma expander
Maternal postpartum anaemia (haemoglobin 24–48 hours postpartum) · management of retained placenta
Umbilical vein injection for management of retained placenta (2021) · Cochrane
no estimate extractedNRNo studies
Saline solution vs expectant management
Addition of therapeutic uterotonics · management of retained placenta
Umbilical vein injection for management of retained placenta (2021) · Cochrane
no estimate extractedNRNo studies
Antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) vs no treatment/placebo
Maternal death · pregnant women at increased risk of VTE during pregnancy and the early postnatal period
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period (2021) · Cochrane
no estimate extractedNRNo studies
Peripartum/postnatal prophylaxis: UFH vs no treatment
Maternal death · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period (2021) · Cochrane
no estimate extractedNRNo studies
Peripartum/postnatal prophylaxis: UFH vs no treatment
Adverse effects sufficient to stop treatment · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period (2021) · Cochrane
no estimate extractedNRNo studies
Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH
Maternal death · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1…
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period (2021) · Cochrane
no estimate extractedNRNo studies
Peripartum/postnatal prophylaxis (caesarean): LMWH vs UFH
Adverse effects sufficient to stop treatment · women giving birth by elective or emergency caesarean (elective or emergency (1 trial), elective cesarean only (1…
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period (2021) · Cochrane
no estimate extractedNRNo studies
Postnatal prophylaxis: LMWH vs no treatment/placebo
Adverse effects sufficient to stop treatment · women at increased risk of VTE in the early postpartum period
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period (2021) · Cochrane
no estimate extractedNRNo studies
Antenatal (± postnatal) prophylaxis: LMWH vs UFH
Maternal death · pregnant women at increased risk of VTE during pregnancy and the early postnatal period
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period (2021) · Cochrane
no estimate extractedNRNo studies
Early discharge vs standard discharge
Maternal mortality within 6 weeks ‐ not reported · healthy mothers and term infants
Early postnatal discharge from hospital for healthy mothers and term infants (2021) · Cochrane
no estimate extractedNRNo studies
Paracetamol (single administration, any dose) vs placebo
Neonatal drug adverse effects · women with perineal pain following childbirth
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period (2021) · Cochrane
no estimate extractedNRNo studies
Probiotics vs placebo
Diabetes · preventing gestational diabetes
Probiotics for preventing gestational diabetes (2021) · Cochrane
no estimate extractedNRNo studies
Probiotics vs placebo
Neurodisability · preventing gestational diabetes
Probiotics for preventing gestational diabetes (2021) · Cochrane
no estimate extractedNRNo studies
Probiotics vs placebo
Perineal trauma · preventing gestational diabetes
Probiotics for preventing gestational diabetes (2021) · Cochrane
no estimate extractedNRNo studies