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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
856 questions in 87 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Inhalation before vs after airway clearance techniques Measures of sputum clearance · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation before vs after airway clearance techniques LCI · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation before vs after airway clearance techniques Adverse events · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation during vs after airway clearance techniques QoL · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation during vs after airway clearance techniques Measures of sputum clearance · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation during vs after airway clearance techniques LCI · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation during vs after airway clearance techniques Adverse events · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation before vs during airway clearance techniques QoL · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Inhalation before vs during airway clearance techniques Adverse events · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control Vitamin E total lipid ratio · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Neuropathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Retinopathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control BMI · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Height · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control FEV1 % predicted: change from baseline · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control Neuropathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control Retinopathy due to vitamin E deficiency · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control BMI · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control Height · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: water‐soluble vitamin E vs control FEV1 % predicted: change from baseline · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fat‐soluble vitamin E vs control Vitamin E total lipid ratio · children and adults with cystic fibrosis Vitamin E supplementation in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Mood or personal well‐being · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ computerised learning vs no intervention Physical health · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ computerised learning vs no intervention Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ computerised learning vs no intervention Family adjustment · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Coping strategies · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control QoL · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ auto‐hypnosis (self‐hypnosis) vs control Family adjustment · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Mood or personal well‐being · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Coping strategies · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment QoL · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ relaxation (progressive or self control) vs no treatment Family adjustment · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Cost of psychological intervention · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ DVD plus information booklet vs information booklet alone Family adjustment · adults and children with hemophilia Psychological interventions for people with hemophilia (2020) · Cochrane | no estimate extracted | NR | No studies |
Vitamin D 100,000 IU/month vs 12,000 IU/month HRQoL (using a validated scale) · people with sickle cell disease Vitamin D supplementation for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Vitamin D vs placebo Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease Vitamin D supplementation for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Vitamin D vs placebo Acute chest syndrome · people with sickle cell disease Vitamin D supplementation for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Vitamin D vs placebo Respiratory infections · people with sickle cell disease Vitamin D supplementation for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Vitamin D 100,000 IU/month vs 12,000 IU/month Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease Vitamin D supplementation for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Final height and change in height · people with thalassaemia (any age) Growth hormone therapy for people with thalassaemia (2020) · Cochrane | no estimate extracted | NR | No studies |
Long‐term RBC transfusion vs standard care Cognitive function ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Long‐term RBC transfusion vs standard care Quality of life ‐ not reported · prevention of SCI in people with SCD and abnormal TCD velocities Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Transfusions continued vs transfusions halted Cognitive function ‐ not reported · prevention of SCI in people with SCD and normalised TCD velocities Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Transfusions continued vs transfusions halted Quality of life ‐ not reported · prevention of SCI in people with SCD and normalised TCD velocities Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs RBC transfusions Cognitive function ‐ not reported · prevention of SCI in people with SCD who have not had a stroke (primary prevention) Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs RBC transfusions Quality of life ‐ not reported · prevention of SCI in people with SCD who have not had a stroke (primary prevention) Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs RBC transfusion Cognitive function ‐ not reported · prevention of SCI in people with SCD who had a stroke (secondary prevention) Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs RBC transfusion Quality of life ‐ not reported · prevention of SCI in people with SCD who had a stroke (secondary prevention) Interventions for preventing silent cerebral infarcts in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |