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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

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Review versions

856 questions in 87 reviews · Cystic Fibrosis and Genetic Disorders

current versions

No studies 856 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Pine bark extract vs control Investigator‐reported · adults with diabetes mellitus type I Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control All‐cause mortality · adults with diabetes mellitus type I Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control Serious adverse events · adults with diabetes mellitus type I Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Participant‐reported · adults with diabetes mellitus type II Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Investigator‐reported · adults with diabetes mellitus type II Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Investigator‐reported · children and adults with asthma diagnosed by American Thoracic Society criteria Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo All‐cause mortality · adults with diabetes mellitus type II Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Serious adverse events · adults with diabetes mellitus type II Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Participant‐reported · adults with diabetes mellitus type I and II combined Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Investigator‐reported · adults with diabetes mellitus type I and II combined Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo All‐cause mortality · adults with diabetes mellitus type I and II combined Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Serious adverse events · adults with diabetes mellitus type I and II combined Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Participant‐reported · men with erectile dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Investigator‐reported · men with erectile dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo All‐cause mortality · men with erectile dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Serious adverse events · men with erectile dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control Participant‐reported · women with sexual dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control Investigator‐reported · women with sexual dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control All‐cause mortality · women with sexual dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control Serious adverse events · women with sexual dysfunction Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Participant‐reported · adults with osteoarthritis of the knee Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Investigator‐reported · adults with osteoarthritis of the knee Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo All‐cause mortality · adults with osteoarthritis of the knee Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo All‐cause mortality · children and adults with asthma diagnosed by American Thoracic Society criteria Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Serious adverse events · adults with osteoarthritis of the knee Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control Participant‐reported · post‐menopausal women with osteopenia Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control Investigator‐reported · post‐menopausal women with osteopenia Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control All‐cause mortality · post‐menopausal women with osteopenia Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs control Serious adverse events · post‐menopausal women with osteopenia Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Participant‐reported · adults with a traumatic brain injury Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Serious adverse events · children and adults with asthma diagnosed by American Thoracic Society criteria Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Investigator‐reported · adults with a traumatic brain injury Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo All‐cause mortality · adults with a traumatic brain injury Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Serious adverse events · adults with a traumatic brain injury Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Pine bark extract vs placebo Participant‐reported · children with ADHD Pine bark (Pinus spp.) extract for treating chronic disorders (2020) · Cochrane	no estimate extracted	NR	No studies
Vitamin K vs control Time to cessation of bleeding · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Intervention NR QoL: CFQ‐R · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Intervention NR QoL: CFQoL · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Adverse events · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Intervention NR PIVKA II levels: change in PIVKA II (ng/mL) · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Vitamin K vs control QoL: CFQ‐R · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Vitamin K vs control QoL: CFQoL · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Vitamin K vs control Adverse events · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Vitamin K vs control Uncarboxylated osteocalcin: change in carboxylation of osteocalcin (% Glu‐OC) · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Time to cessation of bleeding · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Bone mineral density: lumbar spine z score · people with cystic fibrosis Vitamin K supplementation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol) Lung function: FEV1 mL% predicted (change from baseline) · children and young people with CF Inhaled mannitol for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Summary of findings ‐ Inhaled mannitol vs dornase alfa Lung function: FEV1 % predicted · children and young people with CF Inhaled mannitol for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa Lung function: FEV1 % predicted · children and young people with cystic fibrosis Inhaled mannitol for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies
Inhalation before vs after airway clearance techniques QoL · adults and children with cystic fibrosis Timing of hypertonic saline inhalation for cystic fibrosis (2020) · Cochrane	no estimate extracted	NR	No studies