What do systematic reviews say?

9 questions · 9 findings · 7 reviews · Dental caries

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No studies found 9 · 100%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

Quality of life · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
Quality of life was a planned (protocol) outcome but no included trial provided usable quality-of-life data; the protocol was modified to report only survival/response outcomes.
0 studies
No studies found

Interdental brushing plus toothbrushing vs Toothbrushing alone

Quality of life · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
Not estimable. No included study assessed quality of life as an outcome. (See comment)
0 studies
No studies found

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Quality of life · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
Not estimable. No included study assessed quality of life as an outcome. (See comment)
0 studies
No studies found

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Quality of life · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)

The review found no eligible studies for this question.

1 finding from 1 review

Flossing for the management of periodontal diseases and dental caries in adults 2011 · Cochrane All outcomes
Not estimable (0 studies). See comment: No included study assessed quality of life as an outcome.
0 studies
No studies found

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Oral health-related quality of life · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

No included study reported oral health-related quality of life (a planned outcome), so no evidence is available.

1 finding from 1 review

Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent teeth - a… 2025 All outcomes
>=6 months · Dental clinical settings (multiple countries)
no estimate extracted
0 studies
No studies found

Partial pulpotomy vs Full (complete) pulpotomy

Oral health-related quality of life · Mature permanent (molar) teeth with deep caries and symptoms indicative of irreversible pulpitis (spontaneous pain)

No included study reported oral health-related quality of life (a planned outcome), so no evidence is available.

1 finding from 1 review

The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital permanent teeth… 2025 All outcomes
>=6 months · University dental clinics, India (single-centre)
no estimate extracted
0 studies
No studies found

Chlorhexidine gel (0.12%) vs no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine treatment for the prevention of dental caries in children and adolescents 2015 · Cochrane All outcomes
Neither of these trials reported on the other secondary outcomes such as measures of pain, quality of life, patient satisfaction or direct and indirect costs of interventions.
0 studies
No studies found

Chlorhexidine varnish vs placebo or no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine treatment for the prevention of dental caries in children and adolescents 2015 · Cochrane All outcomes
No trials reported on pain, quality of life, patient satisfaction or costs.
0 studies
No studies found

Single full-coverage metal-ceramic crown over composite core and post vs Direct adhesive composite restoration with post (conventional filling, no crown)

Patient satisfaction / quality of life (validated measure) · People with a permanent tooth that has undergone endodontic (root canal) treatment

The review found no eligible studies for this question.

1 finding from 1 review

Single crowns versus conventional fillings for the restoration of root‐filled teeth 2015 · Cochrane All outcomes
This outcome was not reported nor measured by the study. The abstract confirms no evidence was available for any secondary outcome.
Studies not reported
No studies found