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What do systematic reviews say?

8 questions · 8 findings · 4 reviews · Pain, Palliative and Supportive Care

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No studies found 8 · 100%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Opioids vs active comparators

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs placebo

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amitriptyline vs gabapentin

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Citalopram vs placebo

Participant‐reported pain relief of 30% or greater · children (4 to 18 years) with functional abdominal pain disorders

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amitriptyline vs placebo

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs amitriptyline

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical clonidine (TC) vs active comparators

Participant‐reported pain relief of 30% or greater · adults with painful diabetic neuropathy

The review found no eligible studies for this question.

1 finding from 1 review

Topical clonidine for neuropathic pain in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found