What do systematic reviews say?

Withdrawals due to adverse events · adults with sickle cell disease in a vaso‐occlusive crisis

Serious adverse events maximum · patients with suspected or diagnosed myocardial infarction

Serious adverse events: infection · people with implantable ventricular assist devices

Withdrawals due to adverse events · patients with hip osteoarthritis

Withdrawals due to adverse events · patients with hip osteoarthritis

Withdrawals due to adverse events · patients with hip osteoarthritis

Withdrawals due to adverse events · patients with hip osteoarthritis

Withdrawals due to adverse events · patients with hip osteoarthritis

Any adverse events ‐ not reported · depression in adults

Any adverse events ‐ not reported · depression in adults

Adverse events (number of events) · people with acute HBV infection

Adverse events: abscess formation · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

Adverse events and drug reactions · Subfertile women undergoing in vitro maturation

Withdrawals due to adverse events

Number and type of adverse events · hospitalised people with early HCC treated with PEI, PAI, or surgery.

Withdrawals due to adverse events · patients with iliotibial band friction syndrome (knee tendinitis)

Withdrawals due to adverse events · anemia in patients with rheumatoid arthritis

Secondary outcome: all adverse events · People who may be at risk for primary hypertension

Vomiting · people with moderate to severe cancer pain

Non‐serious adverse events Maximum · neonates and children with hospital‐acquired pneumonia