Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Fluorine showed no significant difference in 24 h bond strength (MD 1.441, 95% CI -5.099 to 7.980; Moderate certainty).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Etch-and-Rinse adhesive + biological ACAD protocol network, Flavonoids vs Fluorine showed no significant difference in 24 h bond strength (MD 4.241, 95% CI -2.652 to 11.135; Moderate certainty).
2 findings from 1 review
Postoperative pain (patient-reported) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…
The effect of material choice (MTA vs CaOH) on postoperative pain is unclear: two small studies used different methods and reported contradictory results, so no meta-analysis was performed (ungraded).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Calcium Phosphate showed no significant difference in 24 h bond strength (MD -0.009, 95% CI -4.076 to 4.058; Low certainty).
3 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, HEMA vs Control showed no significant difference in 24 h bond strength (MD 1.899, 95% CI -3.210 to 7.009; Low certainty).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Calcium showed no significant difference in 24 h bond strength (MD 2.654, 95% CI -3.216 to 8.524; Moderate certainty).
2 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Calcium showed no significant difference in 24 h bond strength (MD 1.964, 95% CI -5.802 to 9.730; Moderate certainty).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Fluorine showed no significant difference in 24 h bond strength (MD 2.131, 95% CI -2.213 to 6.475; Low certainty).
3 findings from 1 review
Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…
Biodentine and calcium hydroxide did not differ significantly in clinical and radiographic success (OR 3.14, 95% CI 0.91 to 10.86; ungraded subgroup analysis).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Control showed no significant difference in 24 h bond strength (MD 1.530, 95% CI -2.373 to 5.434; Moderate certainty).
3 findings from 1 review
Plaque control · Children or adolescents
One RCT reported superior plaque control with a gamified mobile health app versus a conventional method; no effect estimate or GRADE assessment was reported.
1 finding from 1 review
Improved caries prognosis via restored oral microbiota · Patients after dental filling
Adjuvant postbiotics after dental filling improve caries prognosis by restoring the oral microbiota in one RCT (ungraded).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Etch-and-Rinse adhesive + chemical ACAD protocol network, Peptide vs HAp showed no significant difference in 24 h bond strength (MD -0.288, 95% CI -7.988 to 7.411; Very Low certainty).
2 findings from 1 review
Regular use rate · Children or adolescents
One RCT reported a 72.4% regular-use rate with a gamified mobile health app versus 48.3% with a nongamified intervention; no GRADE assessment was reported.
1 finding from 1 review
Regular use rate 72.4% (gamified mobile app) vs 48.3% (nongamified)
1 study · In one study, the regular use rate was significantly higher (72.4%) in the gamified mobile health app group than in the nongamified intervention group (48.3%). participants
GRADE not reported
Immediate (24 h) resin-dentin bond strength (MPa) · permanent human teeth with artificial caries-affected dentin
Peptide minus Silica was -0.690 MPa (95% CI -7.941 to 6.560) at 24 h.
1 finding from 1 review
Serum IgG antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines elicited increased serum IgG antibody responses across the animal studies (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Etch-and-Rinse adhesive + biological ACAD protocol network, Flavonoids showed 12.771 MPa lower 24 h bond strength than Calcium Phosphate (MD -12.771, 95% CI -20.538 to -5.003; Moderate certainty).
2 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Etch-and-Rinse adhesive + biological ACAD protocol network, Flavonoids showed 8.438 MPa higher 24 h bond strength than Control (MD 8.438, 95% CI 2.289 to 14.587; Moderate certainty).
2 findings from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, HEMA vs Calcium showed no significant difference in 24 h bond strength (MD 3.023, 95% CI -3.815 to 9.861; Moderate certainty).
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs HEMA showed no significant difference in 24 h bond strength (MD -0.369, 95% CI -6.728 to 5.990; Low certainty).
1 finding from 1 review