Overall survival · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine (intravenous) showed no clear difference in overall survival compared with amifostine (subcutaneous); GRADE not reported.
1 finding from 1 review
HR 1.36 [0.89, 2.10]
1 study
GRADE not reported
Implant probing pocket depth (PPD) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
Metal-free implant abutments (zirconia) showed no clear difference in implant probing pocket depth (PPD) compared with metal implant abutments (titanium); GRADE not reported.
1 finding from 1 review
Low birth weight < 1500 g · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes low birth weight < 1500 g compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).
1 finding from 1 review
Bridge complications · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
It is very uncertain whether metal-free FDPs (lithium disilicate) changes bridge complications compared with metal-ceramic FDPs (very low certainty).
1 finding from 1 review
Oral mucositis (moderate to severe) · Adults with cancer receiving treatment
It is very uncertain whether granulocyte-macrophage colony-stimulating factor (GM-CSF) changes oral mucositis (moderate to severe) compared with placebo or no treatment (very low certainty).
2 findings from 1 review
Oral pain · Adults with cancer receiving treatment
Granulocyte-macrophage colony-stimulating factor (GM-CSF) showed no clear difference in oral pain (mean pain score, 0 to 10 scale) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Interruptions to cancer treatment (chemotherapy delays/discontinuations) · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (chemotherapy… compared with placebo; GRADE not reported.
1 finding from 1 review
Oral mucositis (any severity) · Adults receiving chemotherapy alone for colorectal cancer
Intestinal trefoil factor (ITF), oral spray led to lower oral mucositis (any severity) compared with placebo; GRADE not reported.
1 finding from 1 review
Xerostomia (other Chinese medicines) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Bridge failure · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region
1 finding from 1 review
No FDP failures were reported in either group at 12, 36, 60 or 120 months (18 participants; 17 at 120 months).
1 study · 18 participants
Very low
Overall survival · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
It is very uncertain whether pilocarpine changes overall survival compared with no treatment/placebo (very low certainty).
1 finding from 1 review
Complications: chronic wound pain · Adults (>16 years old) undergoing orthognathic surgery
It is very uncertain whether resorbable (bioresorbable) plates or screws for fixation changes postoperative chronic or lasting pain (wound discomfort) at 4 to 6… compared with titanium plates or screws for fixation (very low certainty).
1 finding from 1 review
Oral pain · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Polaprezinc led to lower oral pain (severe, > 2 on 0-3 scale) compared with azulene oral rinse; GRADE not reported.
1 finding from 1 review
Aesthetics · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region
The review found no eligible studies for this question.
1 finding from 1 review
Patient response: satisfaction with treatment (satisfactory vs unsatisfactory) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in patient response: satisfaction with treatment (satisfactory vs… compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Overall survival · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Time off school or work · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Other oral related symptoms (oral discomfort, eating difficulty, mucosal pain, oral complications) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Xerostomia (grade >= 2, 0-4 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine (intravenous) led to lower xerostomia (grade >= 2, 0-4 scale) compared with amifostine (subcutaneous); GRADE not reported.
2 findings from 1 review
Interruptions to cancer treatment (unscheduled radiotherapy breaks of 5 or more days) · Adults with cancer receiving treatment
Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (unscheduled radiotherapy breaks… compared with placebo; GRADE not reported.
1 finding from 1 review