GM-CSF vs placebo or no treatment: Oral mucositis (moderate to severe)
- Population
- Adults with cancer receiving treatment
- Intervention
- GM-CSF
- Comparison
- placebo or no treatment
- Outcome
- Oral mucositis (moderate to severe)
It is very uncertain whether granulocyte-macrophage colony-stimulating factor (GM-CSF) changes oral mucositis (moderate to severe) compared with placebo or no treatment (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Granulocyte-macrophage colony-stimulating factor (GM-CSF) vs Placebo or no treatment Oral mucositis (moderate to severe) · Adults with cancer receiving treatment · RT to head and neck It is very uncertain whether granulocyte-macrophage colony-stimulating factor (GM-CSF) changes oral mucositis (moderate to severe) compared with placebo or no treatment (very low certainty). Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and… (2017) · Cochrane All outcomes | RR 0.72 [0.49, 1.06] | 1 study · 29 participants | Very low |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) vs Placebo or no treatment Oral mucositis (moderate to severe) · Adults with cancer receiving treatment · BMT/SCT after conditioning for haematological cancers It is very uncertain whether granulocyte-macrophage colony-stimulating factor (GM-CSF) changes oral mucositis (moderate to severe) compared with placebo or no treatment (very low certainty). Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and… (2017) · Cochrane All outcomes | RR 0.94 [0.79, 1.13] | 1 study · 109 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes | 2017-05 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- GM-CSF vs sucralfate · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies · 1 review
- GM-CSF vs sucralfate · Patients with cancer receiving chemotherapy and/or radiotherapy · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.