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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
3,358 questions in 190 reviews · cluster CL0289
current versionsNo studies 599 · 17.8%Ungraded 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mesoporous silica (SiO2) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 1.441 [-5.099, 7.980] | 0 studies | Moderate |
Flavonoids (e.g., quercetin, proanthocyanidin) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + biological ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.241 [-2.652, 11.135] | 0 studies | Moderate |
Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CaOH) Postoperative pain (patient-reported) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible… · 6 hours to 7 days, Primary or secondary dental care Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in… (2025) | Two studies assessed postoperative pain; no meta-analysis was performed due to methodological heterogeneity. Suhag 2019: significantly higher pain in CaOH than MTA at 18 h (CaOH 18.5 +/- 20.8 mm vs MTA 6.3 +/- 9.5 mm,… | 2 studies | Ungraded |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -0.009 [-4.076, 4.058] | 1 study | Low |
HEMA/EGDMA-based desensitizer vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 1.899 [-3.210, 7.009] | 1 study | Low |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Calcium-based agent Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 2.654 [-3.216, 8.524] | 0 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Calcium-based agent Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.044 [-4.923, 3.011] | 0 studies | Low |
Mesoporous silica (SiO2) vs Calcium-based agent Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 1.964 [-5.802, 9.730] | 0 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 2.131 [-2.213, 6.475] | 1 study | Low |
Biodentine (BD) vs Calcium hydroxide (CaOH) Clinical and radiographic success · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible… · >=12 months, Primary or secondary dental care Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in… (2025) | OR 3.14 [0.91, 10.86] | 3 studies · 242 participants | Ungraded |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 1.530 [-2.373, 5.434] | 3 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 3.448 [-1.833, 8.729] | 1 study | Low |
Gamified mobile health app vs Conventional method Plaque control · Children and adolescents aged 18 years or younger The Application of Gamification in Children's Oral Health Management: Systematic Review. (2025) | In the gamified app group in one study, plaque control was superior (P<.05) compared to the conventional method group. | 1 study | Ungraded |
Inactivated-bacteria tablets (Probio-Eco) vs Placebo, fluoride toothpaste, or standard post-filling care (varies by trial) Improved caries prognosis via restored oral microbiota · Patients after dental filling · 14 days, Clinical; salivary/plaque sampling Postbiotics and Dental Caries: A Systematic Review. (2025) | One RCT reported that adjuvant postbiotic tablets after dental filling improved caries prognosis by restoring oral microbiota diversity, structure and function and reducing potentially pathogenic bacteria (Liu 2024);… | 1 study | Ungraded |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + biological ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 18.295 [14.418, 22.172] | 3 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Hydroxyapatite (e.g., nano-HAp) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -0.288 [-7.988, 7.411] | 0 studies | Very low |
Gamified mobile health app vs Nongamified intervention Regular use rate · Children and adolescents aged 18 years or younger · Digital mobile app The Application of Gamification in Children's Oral Health Management: Systematic Review. (2025) | Regular use rate 72.4% (gamified mobile app) vs 48.3% (nongamified) | 1 study · In one study, the regular use rate was significantly higher (72.4%) in the gamified mobile health app group than in the nongamified intervention group (48.3%). participants | Ungraded |
Peptide vs Silica Immediate (24 h) resin-dentin bond strength (MPa) · permanent human teeth with artificial caries-affected dentin · 24 h, in vitro, Self-Etch; chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -0.690 [-7.941, 6.560] | 0 studies | Moderate |
Anticaries vaccine or antibody (DNA, recombinant protein, nanoparticle-adjuvanted, live-vector, plant-based, or passive IgY immunization) targeting S. mutans vs Control (unvaccinated / empty vector / PBS / placebo animals) Serum IgG antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant… · Preclinical (animal laboratory) Assessing the Efficacy and Immunogenicity of Anticaries Vaccine-A Systematic Review and Meta-Analysis. (2025) | no estimate extracted | NR | Ungraded |
Flavonoids (e.g., quercetin, proanthocyanidin) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + biological ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -12.771 [-20.538, -5.003] | 0 studies | Moderate |
Flavonoids (e.g., quercetin, proanthocyanidin) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + biological ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 8.438 [2.289, 14.587] | 1 study | Moderate |
HEMA/EGDMA-based desensitizer vs Calcium-based agent Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 3.023 [-3.815, 9.861] | 0 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs HEMA/EGDMA-based desensitizer Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -0.369 [-6.728, 5.990] | 0 studies | Low |
HEMA/EGDMA-based desensitizer vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 0.360 [-5.589, 6.309] | 0 studies | Moderate |
Inactivated-bacteria tablets vs Not specified Caries prognosis and oral-microbiota diversity structure and function · Patients after dental filling · 14 days, clinical setting Postbiotics and Dental Caries: A Systematic Review. (2025) | no estimate extracted | 1 study | Ungraded |
Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CaOH) Clinical and radiographic success · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible… · >=12 months, Primary or secondary dental care Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in… (2025) | OR 3.05 [1.70, 5.45] | 4 studies · 311 participants | Ungraded |
Flavonoids (e.g., quercetin, proanthocyanidin) vs HEMA/EGDMA-based desensitizer Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 2.705 [-5.654, 11.063] | 0 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Hydroxyapatite (e.g., nano-HAp) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.446 [-0.440, 9.332] | 0 studies | Moderate |
Mesoporous silica (SiO2) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 0.840 [-5.270, 6.950] | 1 study | Low |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + biological ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -2.914 [-8.210, 2.382] | 2 studies | Moderate |
Flavonoids (e.g., quercetin, proanthocyanidin) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.604 [-2.011, 11.219] | 1 study | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs No biomimetic remineralization (control) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.553 [-0.635, 9.740] | 4 studies | Moderate |
Flavonoids (e.g., quercetin, proanthocyanidin) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 3.065 [-4.318, 10.447] | 0 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + biological ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 14.098 [9.684, 18.512] | 2 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Flavonoids (e.g., quercetin, proanthocyanidin) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + biological ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 9.857 [2.588, 17.126] | 0 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Flavonoids (e.g., quercetin, proanthocyanidin) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -3.074 [-10.755, 4.607] | 0 studies | Moderate |
Mesoporous silica (SiO2) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -0.699 [-7.633, 6.234] | 0 studies | Moderate |
Flavonoids (e.g., quercetin, proanthocyanidin) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 5.205 [-1.809, 12.219] | 0 studies | Moderate |
HEMA/EGDMA-based desensitizer vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 2.500 [-2.603, 7.603] | 1 study | Low |
Flavonoids (e.g., quercetin, proanthocyanidin) vs Calcium-based agent Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 5.728 [-2.442, 13.897] | 0 studies | Moderate |
Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Etch-and-Rinse + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 4.672 [-1.320, 10.665] | 2 studies | Moderate |
Mesoporous silica (SiO2) vs HEMA/EGDMA-based desensitizer Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD -1.059 [-9.024, 6.906] | 0 studies | Moderate |
Flavonoids (e.g., quercetin, proanthocyanidin) vs Mesoporous silica (SiO2) Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS), Self-Etch + chemical ACAD Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. (2025) | MD 3.764 [-5.241, 12.769] | 0 studies | Moderate |
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Hospital admission (length of stay) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) Interventions for managing oral submucous fibrosis (2024) · Cochrane | The trials did not measure hospital admission. | 0 studies | No studies |
Physiotherapy (tongue-spatula jaw exercises) vs No active treatment Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Interventions for managing oral submucous fibrosis (2024) · Cochrane | MD 0.50 [-7.72, 8.72] | 1 study · 24 participants | Very low |
Superelastic NiTi arch wire vs Multistrand stainless steel arch wire Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane | Root resorption: not reported | 0 studies | No studies |
Thermoelastic copper NiTi (CuNiTi) arch wire vs Conventional NiTi arch wire Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane | MD 0.00 [-0.51, 0.51] | 1 study · 86 participants | Ungraded |
Occlusal splint vs Another occlusal splint with a different mechanism of action Severity of joint noise · People with temporomandibular disorders (TMD) Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane | Listed in Summary of findings 2 as 'Not reported'; this outcome was not reported by any included study for this comparison. | 0 studies | No studies |
Minimally invasive caries removal (MIT): selective removal to soft dentin, self-limiting chemomechanical removal, or partial/incomplete caries removal vs Conventional caries removal (CT): selective removal to firm dentin, stepwise excavation, or complete caries removal Pulp exposure rate · Patients with deep carious lesions in permanent (mainly posterior) teeth · 1 to 5 years (follow-up varied by study) Comparative Meta-Analysis of Minimally Invasive and Conventional Approaches for Caries Removal in Permanent… (2024) | Mean pulp-exposure percentage (unweighted study-level mean, 4 studies) MIT 1.2% vs CT 8.1% (Wilcoxon = 0.0, p = 0.068; not statistically significant) | 4 studies · 791 participants | Ungraded |
Facemask (RME) or modified facemask vs Other non-surgical orthodontic treatments (mini maxillary protractor, Pushing Splints, modified tandem, Reverse Forsus, reverse Twin Block, reverse chin cup, tongue appliance, Frankel III) Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane | SoF3: Perceived need for surgery in adulthood - Not measured. | 0 studies | No studies |