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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether miswak (Salvadora persica) stick changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with chlorhexidine mouthwash (very low certainty).

1 finding from 1 review

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether PRP (platelet-rich plasma) in cellulose foam placed in extraction… changes incidence of ORN compared with no treatment/placebo (cellulose foam only) placed in extraction socket (very low certainty).

1 finding from 1 review

Hyperbaric oxygen (following replantation) vs control

Pulpal healing at 12 months · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether hyperbaric oxygen (following replantation) changes pulpal healing at 12 months compared with control (very low certainty).

1 finding from 1 review

Individualised oral care plan based on a multidisciplinary assessment vs usual care

Plaque · Adults aged 22 to 57 years with mixed levels of ID; setting residential
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Medium term (6 weeks to 12 months)
    Individualised oral care plan vs usual care. Subjective Oral Hygiene Rating scale 1-5 and Improvement Differential, mean 12 months; SOHR 2.97 (intervention) vs 3.10 (control); improvement differential 38% vs 5%; 79…
    1 study · 79 participants
    Very low

Acupressure at P6 point with sea band vs sham

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with sea band changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure (very low certainty).

1 finding from 1 review

Acupuncture at P6 point with sedation vs Sham (dummy) acupuncture with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupuncture at P6 point with sedation changes reduction in gagging (patient-reported – dichotomous) compared with sham (dummy) acupuncture with sedation (very low certainty).

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Mechanical tongue cleaning (tongue scraper) showed no clear difference in volatile sulphur compounds (VSC) compared with no tongue cleaning; GRADE not reported.

1 finding from 1 review

Acupressure at P6 point with sea band plus sedation vs Sham (dummy) acupressure with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with sea band plus sedation changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Acupressure at P6 point with device vs sham

Presence or absence of gagging · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Hinokitiol gel vs Placebo gel

VSC: hydrogen sulphide · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Hinokitiol gel showed no clear difference in VSC: hydrogen sulphide compared with placebo gel; GRADE not reported.

1 finding from 1 review

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether combined HBO and perioperative antibiotics prior to dental implant… changes incidence of ORN compared with antibiotics alone prior to dental implant therapy (very low certainty).

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Professionally-applied 12,300 ppm F APF foam, every 2 months may leads to lower number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo foam (low certainty).

1 finding from 1 review

Acupuncture at P6 point with sedation vs Sham (dummy) acupuncture with sedation

Presence or absence of gagging · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

1000 mg champignon extract vs 50 mg champignon extract

Patient's family member-reported VAS score (scale 0 to 100) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

1000 mg champignon extract showed no clear difference in patient's family member-reported VAS score (scale 0 to 100) compared with 50 mg champignon extract; GRADE not reported.

1 finding from 1 review

Acupressure at P6 point with thumb vs sham

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with thumb changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure (very low certainty).

1 finding from 1 review

2% mepivacaine, 1:20,000 levonordefrin vs 2% lidocaine, 1:100,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 2% mepivacaine, 1:20,000 levonordefrin changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth

Dento-occlusal results of treatment, measured with the PAR index · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth)

The review found no eligible studies for this question.

1 finding from 1 review

Tooth- and tissue-supported removable partial denture: dual-impression technique with a different material vs An alternative dual-impression technique with a different material

Outcome not reported · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture

The review found no eligible studies for this question.

1 finding from 1 review