Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Fixed tooth-borne expansion (quad-helix) vs Removable tooth-borne expansion (expansion plate)

Canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (quad-helix) may leads to higher canine expansion (inter-canine distance) compared with removable tooth-borne expansion (expansion plate) (low certainty).

1 finding from 1 review

Quad-helix plus multi-bracket appliance vs Expansion arch plus multi-bracket appliance

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Quad-helix plus multi-bracket appliance showed no clear difference in molar expansion compared with expansion arch plus multi-bracket appliance; GRADE not reported.

1 finding from 1 review

Fixed tooth-borne expansion (quad-helix) vs Removable tooth-borne expansion (expansion plate)

Length of treatment · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (quad-helix) probably leads to lower length of treatment compared with removable tooth-borne expansion (expansion plate) (moderate certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Intermediate restorative material (IRM)

Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

It is very uncertain whether mineral trioxide aggregate (MTA) changes success rate at 1 year compared with intermediate restorative material (IRM) (very low certainty).

1 finding from 1 review

Fixed tooth-borne expansion (quad-helix) vs Removable tooth-borne expansion (expansion plate)

Stability of crossbite correction (relapse of molar expansion) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    12 months after correction
    Relapse occurred in 9.1% of both quad-helix and expansion plate groups after one year of follow-up (Godoy 2011)
    1 study · 66 participants
    GRADE not reported

Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)

Overall survival, post-surgery chemotherapy vs surgery alone (no radiotherapy) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).

1 finding from 1 review

Vibrational appliance with fixed appliances vs Fixed appliances

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Vibrational appliance with fixed appliances showed no clear difference in time to alignment (days) compared with fixed appliances only / no vibrational appliance (control); GRADE not reported.

1 finding from 1 review

ARP with demineralised bone matrix, single particle size vs ARP with demineralised bone matrix, multiple particle size

Implant failure rate · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

Haas expander anchored on deciduous second molars vs Haas expander anchored on permanent first molars

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review

Hyrax with conventional expansion screw vs Hyrax with NiTi memory expansion screw

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    after 6-month retention period
    Halicioglu 2014: conventional Hyrax 8.41 (SD 2.09) mm vs NiTi Hyrax 8.94 (SD 1.73) mm; no statistically significant differences for any outcome
    1 study
    GRADE not reported

Self-ligating brackets vs Conventional brackets

Amount of crowding (lower incisor crowding) at 10 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether self-ligating brackets changes amount of crowding (lower incisor crowding) at 10 weeks compared with conventional brackets (very low certainty).

1 finding from 1 review

ARP with alloplast vs ARP with xenograft

Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

Incidence of successfully erupted PDC that were favourably positioned · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

ARP with alloplast vs Extraction alone

Changes in vertical height of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with alloplast changes changes in vertical height of alveolar ridge (mm) compared with extraction alone (very low certainty).

1 finding from 1 review

ARP with allograft plus synthetic cell-binding peptide P-15 vs ARP with allograft without P-15

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review

ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

Changes in bucco-lingual/palatal width of alveolar ridge (mm) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with alloplast plus barrier membrane changes changes in bucco-lingual/palatal width of alveolar ridge (mm) compared with ARP with alloplast without membrane (very low certainty).

1 finding from 1 review

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

Overall treatment time wearing orthodontic appliances · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Haas expander anchored on deciduous second molars vs Haas expander anchored on permanent first molars

Canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    after 5-month retention period
    Ugolini 2015: deciduous 4.2 mm vs permanent 3.3 mm; P<0.01 (more stable anterior expansion with deciduous anchorage)
    1 study
    GRADE not reported