Findings

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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

Length of hospital stay · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Mixed beam (neutron and photon) radiotherapy vs Conventional photon radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Mixed beam (neutron and photon) radiotherapy showed no clear difference in locoregional control compared with conventional photon radiotherapy; GRADE not reported.

1 finding from 1 review

Hypnosis vs control (e.g. usual activities)

Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Hypnosis showed no clear difference in daily mean opiate intake per hour compared with control (treatment as usual); GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Pain on TMJ palpation (ordinal scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in pain on TMJ palpation (ordinal scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Hypnosis vs control (e.g. usual activities)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Hypnosis showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.

1 finding from 1 review

Altered fractionation radiotherapy (hyperfractionated and/or accelerated) vs Conventional (standard) fractionation radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Hyperfractionated/accelerated radiotherapy led to lower locoregional control compared with conventional (standard) fractionation radiotherapy; GRADE not reported.

2 findings from 1 review

Accelerated radiotherapy with concomitant boost vs Conventional (standard) fractionation radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
1 finding from 1 review

Patient-controlled analgesia (PCA) pethidine vs Staff-controlled delivery of pethidine

Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Patient-controlled analgesia (PCA) pethidine showed no clear difference in daily mean opiate intake per hour compared with staff-controlled delivery of pethidine; GRADE not reported.

1 finding from 1 review

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

Completion of treatment · Children aged 10 to 16 years undergoing orthodontic extractions (Braithwaite 2005)

The review found no eligible studies for this question.

1 finding from 1 review
  • Completion of treatment (yes/no) was a protocol-planned primary outcome but was not reported by the included study for this comparison (Braithwaite 2005); one participant in the sedation arm was withdrawn during…
    Studies not reported
    No studies found

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) showed no clear difference in bone gain (horizontal - HDD) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Plaque · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in plaque compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Mechanical debridement with titanium curettes vs Ultrasonic debridement

Plaque · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement with titanium curettes showed no clear difference in plaque compared with mechanical debridement with ultrasonic device; GRADE not reported.

1 finding from 1 review

Powered toothbrush, ultrasonic action vs Multidimensional powered toothbrush

Plaque (level reduction) · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)
1 finding from 1 review

Multidimensional powered toothbrush vs Rotation oscillation powered toothbrush

Plaque (level reduction) · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)
1 finding from 1 review
  • Different powered toothbrushes for plaque control and gingival health 2010 · Cochrane All outcomes
    Short term (1-3 months)
    Analysis 6.1 Plaque < 3 months: 1 trial; totals not selected. The two trials making this comparison (Heasman 1999; Williams 2002) show no significant difference for plaque in the short term (1-3 months).
    1 study
    GRADE not reported

Oral propranolol vs placebo

Change in pain index · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral propranolol (beta-blocker) showed no clear difference in change in pain index compared with placebo; GRADE not reported.

1 finding from 1 review

Non-resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Non-resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Fluconazole (absorbed from GI tract) vs Ketoconazole (absorbed from GI tract)

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Fluconazole (absorbed from GI tract) showed no clear difference in mycological: eradication of oral candidiasis compared with ketoconazole (absorbed from GI tract); GRADE not reported.

1 finding from 1 review

Low dose rate interstitial radiotherapy vs High dose rate interstitial radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Low dose rate interstitial radiotherapy showed no clear difference in locoregional control compared with high dose rate interstitial radiotherapy; GRADE not reported.

1 finding from 1 review