Question · asked by 1 review
Oral propranolol vs placebo: Change in pain index
- Population
- Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of minimum 3 months' duration
- Intervention
- Oral propranolol
- Comparison
- placebo
- Outcome
- Change in pain index
Oral propranolol (beta-blocker) showed no clear difference in change in pain index compared with placebo; GRADE not reported.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral propranolol (beta-blocker) vs Placebo Change in pain index · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to… · 1 week per period (cross-over) Oral propranolol (beta-blocker) showed no clear difference in change in pain index compared with placebo; GRADE not reported. Pharmacological interventions for pain in patients with temporomandibular disorders (2010) · Cochrane All outcomes | Tchivileva et al 2010: statistically significant difference in reduction in pain index between the propranolol treatment period and the placebo treatment period (P = 0.02). | 1 study · 40 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes | 2010-08 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.