Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Oral health assessment · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Blixt-Johansen 1992 (parallel, elderly long-term care, poor oral mucosa): oral mucosa improved in both groups but a much greater reduction in oral pathology in the mucin spray group; no data presented.
    1 study
    GRADE not reported

Carbopol (polyacrylic acid/acetate) spray vs Placebo spray

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review

Intraoral device releasing Biotene Oral Balance gel vs usual care without an aid

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Frost 2002 (crossover, n=30, Sjogren's syndrome): overall mouth dryness favoured the device but only nearly significant (median 4 (IQR 2 to 4) device vs 3 (2 to 4) control; P = 0.056). Speech (P = 0.003) and swallowing…
    1 study · 30 participants
    GRADE not reported

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Duration of relief of dryness · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Mucin spray (Saliva Orthana) showed no clear difference in duration of relief of dryness compared with placebo spray (base without mucin); GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: three-dimensional CT scan (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: three-dimensional CT scan (0 to 3 grading… compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Chewing gum vs Saliva substitute spray

Patient preference · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Chewing gum (mechanical saliva stimulant) led to lower patient preference compared with saliva substitute spray; GRADE not reported.

1 finding from 1 review
  • Bots 2005: statistically significant preference for chewing gum over Xialine spray, 39/49 (80%) preferred gum vs 10/49 (20%) spray (Chi2 17.16, df=1; P < 0.001) (Analysis 2.3). Davies 2000: more people preferred gum,…
    1 study · 65 participants
    GRADE not reported

Arthroscopy vs Arthrocentesis

Maximal mouth opening (interincisal distance) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy led to higher maximum interincisal opening (mm) after 12 months compared with arthrocentesis; GRADE not reported.

1 finding from 1 review

Buffered 'Prophylin' prophylactic gel vs Placebo gel

Oral health (oral pH, cariogenic bacteria, Candida) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review

Passive maxillary/obturating plate (worn until surgical closure of soft palate) vs No plate

Length (cm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Passive maxillary/obturating plate (worn until surgical closure of… showed no clear difference in length (cm) compared with no plate; GRADE not reported.

1 finding from 1 review