Findings

What do systematic reviews say?

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

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No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Acupuncture vs sham

Dry mouth (xerostomia) · Adults with dry mouth due to radiotherapy (head and neck cancer) or Sjogren's Syndrome

Acupuncture showed no clear difference in dry mouth (mouth dryness, different scales) compared with placebo (sham acupuncture) (low certainty).

1 finding from 1 review

Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
End of treatment (4-6 weeks)
SMD -0.34 [-0.81, 0.14]
2 studies · 70 participants
Low

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Patients not using rescue medication at 6 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher patients not using rescue medication at 6 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
6 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
RR 1.50 [1.25, 1.79]
4 studies · 542 participants
High

Toluidine blue (visual staining) vs No screening

Outcome not reported · Planned population: general population or high-risk / opportunistic screening groups (no eligible study)

The review found no eligible studies for this question.

1 finding from 1 review

Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
There was no evidence to support the use of adjunctive technologies like toluidine blue, brush biopsy or fluorescence imaging as a screening tool to reduce oral cancer mortality; no eligible randomised controlled trial…
0 studies
No studies found

Immediate loading vs Conventional loading

Implant failure · Patients who are having osseointegrated root-form dental implants

Immediate loading showed no clear difference in implant failure compared with conventional loading; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 1.50 [0.60, 3.77]
10 studies
GRADE not reported

Powered toothbrush (any mode of action) vs Manual toothbrush

Unstimulated whole saliva (UWS) · Adults with medication-related dry mouth

Powered toothbrush showed no clear difference in unstimulated whole saliva (UWS) compared with manual toothbrush; GRADE not reported.

1 finding from 1 review

Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
45 minutes after brushing
MD -0.07 [-0.74, 0.60]
1 study
GRADE not reported

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Postoperative infection · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications 2013 · Cochrane All outcomes
3 to 5 months
RR 0.69 [0.36, 1.35]
6 studies · 1162 participants
GRADE not reported

Two miniplates (transbuccal approach) vs One miniplate plus two screws (intraoral approach at external oblique ridge)

Restoration of function (malocclusion) · Adults with fractures of the mandibular angle

Two miniplates (transbuccal approach) showed no clear difference in restoration of function (malocclusion) compared with one miniplate plus two screws (intraoral approach at external…; GRADE not reported.

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
Angle of mandible only
RR 0.46 [0.05, 4.17]
1 study
GRADE not reported

Intraoral distalising appliance vs Headgear (extraoral appliance)

Movement of upper incisor teeth (mm) · Children and adolescents (aged 16 years or less at the start of treatment) undergoing orthodontic treatment to distalise upper first…

Intraoral distalising appliance may leads to higher movement of upper incisor teeth (mm) compared with headgear (extraoral appliance) (low certainty).

1 finding from 1 review

Orthodontic treatment for distalising upper first molars in children and adolescents 2013 · Cochrane All outcomes
MD 1.82 [1.39, 2.24]
4 studies · 150 participants
Low

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Participant satisfaction · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars

The review found no eligible studies for this question.

1 finding from 1 review

Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
Participant satisfaction: No studies assessed this outcome.
Studies not reported
No studies found

Brush biopsy (oral cytology) vs No screening

Outcome not reported · Planned population: general population or high-risk / opportunistic screening groups (no eligible study)

The review found no eligible studies for this question.

1 finding from 1 review

Screening programmes for the early detection and prevention of oral cancer 2013 · Cochrane All outcomes
There was no evidence to support the use of adjunctive technologies like toluidine blue, brush biopsy or fluorescence imaging as a screening tool to reduce oral cancer mortality; no eligible randomised controlled trial…
0 studies
No studies found

Transbuccal miniplate combined with intraoral approach vs Intraoral approach alone

Wound dehiscence · Adults with fractures of the mandibular angle

Transbuccal miniplate combined with intraoral approach led to lower wound dehiscence compared with intraoral approach alone; GRADE not reported.

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
3 months · Angle of mandible only
RR 0.43 [0.19, 0.98]
1 study · 138 participants
GRADE not reported

Dental repositioning vs Spontaneous re-eruption, orthodontic repositioning, or surgical repositioning

Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes
Minimum 12 months follow-up
Types of dental repositioning: to compare spontaneous re-eruption, orthodontic repositioning or surgical repositioning. Main results: No randomised or quasi-randomised controlled trials were found; no study was…
0 studies
No studies found

Pre-radiotherapy extraction of diseased molar teeth vs Conservative treatment (restoration of the teeth and leaving them in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Overall survival · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Intraoral distalising appliance vs Another (different) intraoral distalising appliance

Movement of upper first molars (mm) · Children and adolescents (aged 16 years or less at the start of treatment) undergoing orthodontic treatment to distalise upper first…

1 finding from 1 review

Orthodontic treatment for distalising upper first molars in children and adolescents 2013 · Cochrane All outcomes
SoF table 3 (intraoral vs other intraoral appliance). Assumed risk "Not estimated"; Corresponding risk "Not estimated"; Relative effect "Meta-analysis not appropriate". Quality: very low. Comment: "No pooled estimate…
3 studies · 93 participants
Very low

Immediate loading vs Early loading

Implant failure · Patients who are having osseointegrated root-form dental implants

Immediate loading showed no clear difference in implant failure compared with early loading; GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: different times for loading dental implants 2013 · Cochrane All outcomes
1 year
RR 0.65 [0.26, 1.64]
5 studies
GRADE not reported

Pre-radiotherapy extraction of healthy molar teeth vs Conservative treatment (leaving the teeth in place during radiotherapy, with oral health education and disease prevention: oral hygiene, fluoride, diet advice)

Delay in start of radiation treatment · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…

The review found no eligible studies for this question.

1 finding from 1 review

Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Acupuncture vs sham

Patient satisfaction with treatment · Adults with dry mouth due to radiotherapy (head and neck cancer) or Sjogren's Syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Locking plate vs 2 mm non-locking titanium plates

Average pain scores (0-100 VAS) · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
Agarwal 2011 reported a significant decrease in VAS pain from week 1 to the 3-month follow-up, with no difference between groups at the follow-up visits, but presented no supporting data.
1 study
GRADE not reported

Immediate mobilization vs 2 weeks delayed mobilization (IMF)

Average pain scores (0-100 VAS) · Adults with mandibular fractures excluding condyles (fixed with 2 mm titanium miniplates)

1 finding from 1 review

Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes
Pain (scale 1 to 10) was minor in both groups with no significant differences (Table 4): 6 weeks 1.55 vs 1.20; 3 months 1.00 vs 2.64; 6 months 1.30 vs 2.71 (immediate release vs IMF). 95% confidence interval not…
1 study
GRADE not reported

Powered toothbrush (any mode of action) vs Manual toothbrush

Stimulated whole saliva (SWS) · Adults with medication-related dry mouth

Powered toothbrush showed no clear difference in stimulated whole saliva (SWS) compared with manual toothbrush; GRADE not reported.

1 finding from 1 review

Interventions for the management of dry mouth: non‐pharmacological interventions 2013 · Cochrane All outcomes
5 minutes after brushing
MD -0.13 [-1.92, 1.66]
1 study
GRADE not reported