Metronidazole gel 25% (local antibiotic) showed no clear difference in change in probing pocket depth compared with ultrasonic debridement; GRADE not reported.
Mechanical debridement with titanium curettes showed no clear difference in change in probing pocket depth compared with mechanical debridement with ultrasonic device; GRADE not reported.
Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.
Phosphoric etching (acid) gel showed no clear difference in change in probing pocket depth compared with mechanical debridement and polishing; GRADE not reported.
Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing pocket depth (PPD) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.
Enamel matrix derivative (EMD; Emdogain) showed no clear difference in change in probing pocket depth (PPD) compared with guided tissue regeneration (GTR) with barriers (low certainty).
Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).
Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth (worst sites) compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.
Occlusal adjustment as an adjunct to non-surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.
Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.