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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
82 questions in 16 reviews · cluster CL0286
current versionsNo studies 34 · 41.5%Ungraded 33 · 40.2%Very low 15 · 18.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | RR 1.5 [0.4, 5.0] | 1 study · 166 participants | Ungraded |
Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel) Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3% Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3% Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel) Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | RR 0.65 [0.2, 2.0] | 1 study · 161 participants | Ungraded |
Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% vs Normal saline Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | Only a graph plot of 'average pain' over the 7-day postoperative period in each group was provided; this could not be transformed into usable data for the review's prespecified outcomes. | 1 study | Ungraded |
Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3% Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5% (also 2.5%) vs Sodium hypochlorite 1% Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5% (also 2.5%) vs Sodium hypochlorite 1% Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | RR 0.22 [0.051, 0.91] | 1 study · 111 participants | Ungraded |
Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Chlorhexidine, 0.2% to 2% (solution or gel) Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% vs Normal saline Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5% vs Sodium hypochlorite 5% with proteolytic enzyme Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse Proportion of participants or samples with positive bacterial growth culture, up to 72 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | Vital bacterial counts decreased after the active intervention (MTAD) but live bacteria were present in all of the samples; no further usable data reported. | 1 study | Ungraded |
Sodium hypochlorite 5% (also 2.5%) vs Sodium hypochlorite 1% Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | no estimate extracted | 0 studies | No studies |
Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3% Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or… Irrigants for non‐surgical root canal treatment in mature permanent teeth (2012) · Cochrane | RR 1.22 [0.4, 4.2] | 1 study · 167 participants | Ungraded |
Physostigmine gel (1.8 mg) vs Placebo gel Xerostomia (VAS mouth dryness, AUC over 180 min) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's… Interventions for the management of dry mouth: topical therapies (2011) · Cochrane | Khosravani 2009 (crossover, low risk of bias, n=17): reduction in oral dryness (VAS area-under-curve over first 180 minutes) after 1.8 mg physostigmine gel; reported graphically, not usable for meta-analysis. | 1 study · 17 participants | Ungraded |
Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus) Augmentation procedure (partial) failure · Patients with vertically deficient posterior/anterior mandibular ridges needing implants · Up to 3 years post-loading Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental… (2009) · Cochrane | OR 0.88 [0.05, 16.74] | 1 study · 17 participants | Ungraded |
Vertical GBR with non-resorbable titanium-reinforced barriers vs Vertical GBR with resorbable barriers supported by osteosynthesis plates Augmentation procedure failure · Patients with vertically deficient posterior/anterior mandibular ridges needing implants · About 4.5 months Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental… (2009) · Cochrane | OR 2.22 [0.17, 28.86] | 1 study · 22 participants | Ungraded |
Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment) Adverse effects (e.g. thermal sensitivity, over-eruption, TMJ symptoms, poor aesthetics, reduced oral hygiene) · Adults (aged 18 years or older) with a clinical diagnosis of (chronic) periodontitis · Minimum 3 months (planned) Occlusal interventions for periodontitis in adults (2008) · Cochrane | no estimate extracted | 0 studies | No studies |
Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment) Adverse effects (e.g. thermal sensitivity, over-eruption, TMJ symptoms, poor aesthetics, reduced oral hygiene) · Adults (aged 18 years or older) with a clinical diagnosis of (chronic) periodontitis · Minimum 3 months (planned) Occlusal interventions for periodontitis in adults (2008) · Cochrane | no estimate extracted | 0 studies | No studies |
Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery) Treatment / surgical procedure time · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved… Guided tissue regeneration for periodontal infra-bony defects (2006) · Cochrane | MD 23.9 | 1 study | Ungraded |
Ceramic inlays (all types) vs Gold inlay Postoperative sensitivity/pain · Adults who require restorative treatment in posterior teeth · 1 week Ceramic inlays for restoring posterior teeth (2003) · Cochrane | Postoperative sensitivity was evaluated 1 week after placement. No teeth with ceramic inlays were found to have postoperative sensitivity, while one tooth with gold inlay presented sensitivity, which lasted more than 2… | 1 study · 20 participants | Ungraded |