Gap finder
Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
239 questions in 37 reviews · cluster CL0069
current versionsNo studies 4 · 1.7%Ungraded 170 · 71.1%Very low 42 · 17.6%Low 6 · 2.5%Moderate 10 · 4.2%High 7 · 2.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls) Sites with probing depth >= 4 mm · Adults (general and hospital populations assessed in case-control studies) Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. (2021) | SMD 2.071 [0.267, 3.875] | 3 studies | Ungraded |
Observed population vs Not applicable Severe tooth wear prevalence · School children aged 2.6-6.8 years in Abu Dhabi · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Proportion of examined teeth (severe tooth wear) 0.15 | 1 study · 9213 teeth (from 506 children examined) participants | Ungraded |
11-16 remaining teeth vs 25-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 2.27 [1.55, 3.32] | 4 studies · 189120 participants | High |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Multivariable-adjusted Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.30 [1.21, 1.40] | 7 studies · 102254 participants | Moderate |
Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls) Probing depth (PD) · Adults (general and hospital populations assessed in case-control studies) · Other/non-Asia (Da Silva 2019, Iordache 2019, Isola 2017, Pischon 2016) Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. (2021) | SMD 4.86 [1.61, 8.10] | 4 studies | Ungraded |
Observed population vs Not applicable Care index · Preschool children attending Al Ain pediatric dentistry department · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Proportion 6.4 | 1 study · 176 participants | Ungraded |
17-24 remaining teeth vs 25-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 1.73 [1.22, 2.45] | 4 studies · 213202 participants | High |
0-19 remaining teeth vs 20-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Crude Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 2.47 [2.40, 2.54] | 2 studies · 36379 participants | Ungraded |
0-19 remaining teeth vs 20-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 1.84 [1.52, 2.23] | 11 studies · 267575 participants | Low |
Arab non-Emirati nationality vs Reference nationality not stated Dental erosion · Five-year-old preschool children in Sharjah · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | OR 0.27 [0.18, 0.42] | 1 study · 403 participants | Ungraded |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Adjusted for age/sex Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.56 [1.48, 1.65] | 3 studies · 43734 participants | Ungraded |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Multivariable-adjusted Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.02 [1.01, 1.03] | 11 studies · 4467321 participants | Low |
Observed population vs Not applicable Molar-incisor hypomineralization prevalence · School children aged 8-12 years in Dubai public schools · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 27.2 | 1 study · 342 participants | Ungraded |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 1.94 [1.19, 3.15] | 14 studies · 4711667 participants | Low |
Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls) Probing depth (PD) · Adults (general and hospital populations assessed in case-control studies) · Asia (Elimelech 2015, Leung 2011, Mayer 2013) Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. (2021) | SMD 1.113 [0.751, 1.476] | 3 studies | Ungraded |
Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls) Prevalence of periodontitis · Adults (general and hospital populations assessed in case-control studies) Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. (2021) | OR 7.007 [3.529, 13.915] | 3 studies | Ungraded |
1-19 remaining teeth vs 20-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 1.76 [1.41, 2.19] | 8 studies · 222572 participants | High |
Observed population vs Not applicable Care index · Emirati preschool children in Ras Al Khaimah nurseries · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Proportion 3.8 | 1 study · 540 participants | Ungraded |
Female sex vs Male sex Daily tooth brushing · School-aged children in Sharjah · Females Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 98 | 1 study · 803 participants | Ungraded |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Multivariable-adjusted Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.21 [1.07, 1.36] | 5 studies · 101938 participants | Moderate |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Crude Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.73 [1.41, 2.13] | 5 studies · 99303 participants | Ungraded |
Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls) Number of decayed teeth · Adults (general and hospital populations assessed in case-control studies) Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. (2021) | SMD 0.186 [0.007, 0.365] | 3 studies | Ungraded |
Female sex vs Male sex Molar-incisor hypomineralization prevalence · School children aged 8-12 years in Dubai public schools · Females Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 32.6 | 1 study · 342 participants | Ungraded |
Observed population vs Not applicable Dental erosion prevalence · Five-year-old preschool children in Sharjah · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 58.8 | 1 study · 403 participants | Ungraded |
0-19 remaining teeth vs 20-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Crude Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 2.27 [1.50, 3.43] | 1 study · 4380 participants | Ungraded |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Crude Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.01 [1.00, 1.03] | 3 studies · 2219 participants | Ungraded |
Edentulous (0 remaining teeth) vs 20-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 2.65 [1.77, 3.98] | 2 studies · 130669 participants | High |
Early childhood caries (ECC) vs ECC-free children (caries-free controls) Hemoglobin (HGB) level · Preschool children (<6 years) · Overall Iron deficiency and early childhood caries: a systematic review and meta-analysis. (2021) | WMD -9.96 [-15.45, -4.46] | 5 studies · 924 participants | Ungraded |
0-19 remaining teeth vs 20-32 remaining teeth All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Multivariable-adjusted Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.29 [1.21, 1.37] | 10 studies · 305970 participants | Low |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Crude Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.89 [1.80, 1.99] | 3 studies · 98122 participants | Ungraded |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Multivariable-adjusted Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.02 [1.01, 1.03] | 13 studies · 4639644 participants | Low |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 2.93 [1.92, 4.50] | 10 studies · 4697021 participants | Moderate |
Beta-thalassemia major vs Healthy Emirati children Calculus prevalence · Children with beta-thalassemia major in Dubai · Children with beta-thalassemia major Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 28.9 | 1 study | Ungraded |
Observed population vs Not applicable Tooth brushing less than once daily, males in 2016 · Nationally surveyed adolescents in the United Arab Emirates · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 46.1 | 1 study · 24220 participants | Ungraded |
Autism spectrum disorder vs Not applicable Poor oral hygiene prevalence · Autistic children and young adults in Dubai · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 59 | 1 study | Ungraded |
Autism spectrum disorder vs Healthy counterparts Dental-care visit prevalence · Children with autism spectrum disorder in Dubai · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 65 | 1 study | Ungraded |
Edentulous (0 remaining teeth) vs 1-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Adjusted for age/sex Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.49 [1.39, 1.58] | 4 studies · 44937 participants | Ungraded |
Cerebral palsy vs Healthy age- and sex-matched controls Calculus index · Children with cerebral palsy in Dubai · Children with cerebral palsy Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | MEAN 0.56 | 1 study | Ungraded |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Crude Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.01 [0.99, 1.03] | 1 study · 1385 participants | Ungraded |
High snack consumption vs Low snack consumption Mean plaque score · Children aged 5-6 years in Ajman schools · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Adjusted difference 0.13 [0.02, 0.24] | 1 study · 1036 participants | Ungraded |
Observed population vs Not applicable Significant caries index · Preschool children in Dubai · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | MEAN 4.55 | 1 study · 2957 participants | Ungraded |
1-19 remaining teeth vs 20-32 remaining teeth Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | RR 1.69 [1.13, 2.53] | 2 studies · 165066 participants | High |
Incarcerated mother vs Comparison children Plaque prevalence · Preschool children of incarcerated mothers in UAE prison nurseries · Children of incarcerated mothers Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 93.8 | 1 study | Ungraded |
Down syndrome vs Healthy controls Dental erosion prevalence · Children with Down syndrome in Dubai · Children with Down syndrome Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Prevalence 34 | 1 study | Ungraded |
Early childhood caries (ECC) vs ECC-free children (caries-free controls) Iron deficiency (ID) · Preschool children (<6 years) · Sensitivity analysis (Ramos-Gomez et al. 2002 excluded) Iron deficiency and early childhood caries: a systematic review and meta-analysis. (2021) | OR 2.76 [2.42, 3.13] | 7 studies · 9028 participants | Ungraded |
Early childhood caries (ECC) vs ECC-free children (caries-free controls) Iron deficiency anemia (IDA) · Preschool children (<6 years) · Overall Iron deficiency and early childhood caries: a systematic review and meta-analysis. (2021) | OR 2.74 [2.41, 3.11] | 5 studies · 8764 participants | Ungraded |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Adjusted for age/sex Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.02 [1.01, 1.04] | 5 studies · 4421245 participants | Ungraded |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment) Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Adjusted for age/sex Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of… (2021) | HR 1.01 [1.00, 1.03] | 7 studies · 4546574 participants | Ungraded |
Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls) Maximum interincisor distance (mouth opening) · Adults (general and hospital populations assessed in case-control studies) Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. (2021) | SMD -1.061 [-1.546, -0.576] | 4 studies | Ungraded |
Observed population vs Not applicable Restorative index · Preschool children attending Al Ain pediatric dentistry department · Overall Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Proportion 6.4 | 1 study · 176 participants | Ungraded |