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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
5 questions in 4 reviews · intervention: Exposure/condition: systemic-oral · outcome domain: Caries increment (DMFS/DMFT)
current versionsNo studies 0 · 0%Ungraded 4 · 80%Very low 1 · 20%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HAART (highly active antiretroviral therapy, >=3 drugs) vs HIV-positive not receiving HAART (standard ART or HAART-naive) Dental caries severity (DMFT index, permanent dentition) · Children and adolescents under 18 years with HIV · Not specified (case-control), Case-control studies; DMFT index Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a… (2025) | MD 2.02 [1.24, 2.80] | NR | Ungraded |
HAART (highly active antiretroviral therapy, >=3 drugs) vs HIV-positive not receiving HAART (standard ART or HAART-naive) Dental caries severity (dmft index, primary dentition) · Children and adolescents under 18 years with HIV · Not specified (case-control), Case-control studies; dmft index Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a… (2025) | MD 0.66 [-0.26, 1.58] | NR | Ungraded |
Periodontitis vs No periodontitis (periodontal health or gingivitis) Mean DMFT (decayed, missing, filled teeth) · Adults · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | WMD 0.87 [-0.03, 1.76] | 4 studies | Ungraded |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Dental caries experience · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.91 [0.5, 1.65] | 2 studies · 301 participants | Very low |
Preterm birth (oral health / enamel defects) vs Full-term children Caries (DMFT) and enamel defects · Preterm children (about 8 years old) in the United Arab Emirates (Dubai) Oral Health of Children and Adolescents in the United Arab Emirates: A Systematic Review of the Past Decade. (2021) | Alshehhi et al. (Dubai) reported a significantly higher mean DMFT (1.00 vs 0.38) and a 4-times higher prevalence of enamel defects (58.15% vs 24.2%; OR 4.33, 95% CI 2.01-9.36) in preterm vs full-term children, highest… | 1 study | Ungraded |