Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

671 questions · 731 findings · 61 reviews · Drugs and Alcohol

No studies found 57 · 7.8%GRADE not reported 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%

Summary of findings table – disulfiram vs naltrexone

Acceptability ‐ total dropouts · patients with the treatment of cocaine dependence

It is very uncertain whether summary of findings table – disulfiram changes dropout for any reason (number of participants who did not complete… compared with naltrexone (very low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram showed no clear difference in continuous abstinence from cocaine (number of participants who had… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Point abstinence (number of participants who were abstinent at the end of the treatment) · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram may leads to higher point abstinence (number of participants who were abstinent at the… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Acceptability ‐ total dropouts · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram showed no clear difference in dropout for any reason (number of participants who did not complete… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Dropouts due to adverse events · patients with the treatment of cocaine dependence

It is very uncertain whether summary of findings table – disulfiram changes dropout due to adverse events (number of participants who did not… compared with placebo or no pharmacological treatment (very low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Adverse events as N of participants with at least one adverse event objective · patients with the treatment of cocaine dependence

It is very uncertain whether summary of findings table – disulfiram changes any adverse events (number of participants who experienced at least… compared with placebo or no pharmacological treatment (very low certainty).

1 finding from 1 review