Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Eradication therapy combined with periodontal therapy vs eradication therapy alone

Eradication rate of gastric H. pylori · patients with gastric Helicobacter pylori infection

Eradication therapy combined with periodontal therapy probably leads to higher eradication rate of gastric H. pylori compared with eradication therapy alone (moderate certainty).

1 finding from 1 review

Eradication therapy combined with periodontal therapy vs eradication therapy alone

Non‐recurrence rate of gastric H. pylori · patients with gastric Helicobacter pylori infection

Eradication therapy combined with periodontal therapy may leads to higher non‐recurrence rate of gastric H. pylori compared with eradication therapy alone (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP pancreatitis · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) may leads to higher post‐ERCP pancreatitis compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

CBD cannulation success with the randomised technique (before the use of rescue techniques) · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in CBD cannulation success with the randomised technique (before the… compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Overall success of cannulation · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in overall cannulation success compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP bleeding · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP bleeding compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP perforation · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP perforation compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP cholangitis · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in post‐ERCP cholangitis compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

All‐cause mortality · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in mortality compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with improved complete spontaneous bowel movement (CSBM) of greater than three times per week at two‐month · children with chronic constipation

It is very uncertain whether the intervention changes number of participants with improved complete spontaneous bowel… (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with improved colonic transit · children with chronic constipation

It is very uncertain whether the intervention changes number of participants with improved colonic transit (very low certainty).

1 finding from 1 review

Intervention not reported

Colonic transit rate (geometric centre of radioactive substance). Unit indicates position along with intestinal tract. Scale from: 1 (small intestine) to 5 (rectosigmoid area). · children with chronic constipation
1 finding from 1 review

Intervention not reported

Number of participants with improved symptoms related to soiling · children with chronic constipation

It is very uncertain whether the intervention changes number of participants with improved symptoms related to soiling (very low certainty).

1 finding from 1 review