Hypertension (later in life) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No eligible studies examined the influence of complementary feeding practices on later hypertension; this is an evidence gap.
1 finding from 1 review
Accuracy advantage in test case 2 · Dental images of human beings
The review reported a 52% accuracy advantage in Patil test case 2 (Ungraded).
2 findings from 1 review
Dental caries prevalence · Children (deciduous and/or permanent dentition) in low- and middle-income countries
About 39% of children in LMICs had dental caries (pooled prevalence 0.387, 95% CI 0.284 to 0.495; 11 studies; very high heterogeneity I2=99%; not GRADE-rated).
1 finding from 1 review
No formal maternal education prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries
About 10% of children with caries in LMICs had mothers with no formal education (pooled prevalence 0.101, 95% CI 0.033 to 0.201; 3 studies; not GRADE-rated).
1 finding from 1 review
Secondary caries (caries around restorations), load-bearing cavities · Patients with permanent dentition in need of restorations in load-bearing cavities (Class I/II posterior)
In load-bearing cavities, ion-releasing (GIC and compomer) and resin composite restorations show no significant difference in secondary caries (RD -0.00, 95% CI -0.01 to 0.01; not GRADE-rated).
1 finding from 1 review
Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients
Under demineralizing conditions, nHA allowed significantly more enamel demineralization than NaF (MD 1625, 95% CI 553 to 2697; very low certainty).
2 findings from 1 review
Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in linear gingival erythema between ART regimens (very low certainty).
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; failure rates were tabulated by arm.
1 finding from 1 review
Persistent parotid enlargement (WHO clinical stage 2) · Children or adolescents
No significant difference in persistent parotid enlargement between groups (OR 10.36, 95% CI 0.53 to 201.45; single study, very imprecise).
1 finding from 1 review
Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in oral hairy leukoplakia between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 2.75 [0.39, 19.43]
Studies not reported
Very low
Early childhood caries (ECC) - association at lead SNP rs7325099 (13:28104496; nearest gene(s) LNX2, POLR1D, RPL21) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs7325099 near LNX2, POLR1D, RPL21 showed suggestive (not genome-wide significant) association with ECC (Z = 4.485, p = 7.28e-6); genetic association, ungraded.
1 finding from 1 review
Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars
SDF is effective in arresting caries progression in cavitated primary molars overall (pooled ES 0.33, 95% CI 0.26-0.40; ungraded).
1 finding from 1 review
Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
In RCTs, BLISS did not significantly change overweight/obesity risk versus traditional feeding (RR 0.15, 95% CI 0.00 to 17.79; low certainty).
1 finding from 1 review
Contribution to total daily fluoride intake · children
For children in medium-fluoridated areas, the mean contribution was 51% (SD 24%).
1 finding from 1 review
Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in chronic herpes simplex infection between ART regimens (very low certainty).
1 finding from 1 review
Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration
Zirconia crowns showed no significant difference in crown retention versus other restorations at 6 months (RR 1.02, 95% CI 0.94 to 1.11; 3 studies; not GRADE-rated).
2 findings from 1 review
Intervention not reported
Caries experience - mean dfs (descriptive), primary dentition
1 finding from 1 review
Primary maternal education prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries
About 42% of children with caries in LMICs had mothers with primary education (pooled prevalence 0.425, 95% CI 0.280 to 0.576; 7 studies; not GRADE-rated).
1 finding from 1 review
Caries increment, tooth index D(M)FT · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)
Among children aged 5-8 years, net increment in DMFT was not significantly reduced (SMD -0.36); no significant subgroup difference by age.
3 findings from 1 review
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review