Dental caries (association with middle SES) · Children (deciduous and/or permanent dentition) in low- and middle-income countries
Middle SES showed no significant association with dental caries (OR 0.80, 95% CI 0.59 to 1.10; 7 studies; not GRADE-rated).
1 finding from 1 review
Contribution to total daily fluoride intake · children
For children in high-fluoridated areas, the mean contribution was 41% (SD 24%).
1 finding from 1 review
Mucocele · Children or adolescents
No significant difference in mucocele between groups (OR 3.03, 95% CI 0.12 to 75.37; single study).
1 finding from 1 review
Adverse events · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
The review found no eligible studies for this question.
1 finding from 1 review
Immediate bond strength (MPa) · Glass-ionomer cement bonded to caries-affected dentin (in vitro)
SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD -0.36 MPa, 95% CI -1.07 to 0.35; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Glass-ionomer cement bonded to dentin (in vitro), sound or caries-affected
Prior SDF application does not influence the immediate bond strength of glass-ionomer cement to dentin (MD -0.11 MPa, 95% CI -0.54 to 0.31; ungraded).
1 finding from 1 review
Treatment failure (annual failure rate) · Children with carious primary teeth treated by atraumatic restorative treatment (hand-instrument caries removal), no pulp therapy
ART restorations (mainly GIC) had a wide annual failure rate (1.2-37.1%) across 10 RCTs, with technique affecting survival; low to unclear quality of evidence (ungraded).
1 finding from 1 review
Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers
Behaviour change interventions delivered by non-dental health workers produced a small, statistically significant reduction in caries experience at the surface level (dmfs SMD -0.15, 95% CI -0.25 to -0.04; 12 studies); the review judged the overall evidence to be of low quality (not GRADE-rated).
1 finding from 1 review
Alpha diversity (Shannon) · Children providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples
In children, caries-vs-health Shannon alpha diversity differed significantly (ungraded).
1 finding from 1 review
Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Dentinal caries in the primary dentition is associated with about 3.2 times higher odds of dentinal caries in permanent teeth (single study; not GRADE-rated).
1 finding from 1 review
Discrimination of caries vs health (random forest ROC-AUC) · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…
Microbiome-based random forest classifiers could not reliably discriminate caries from health across the combined cohort (best AUC approximately 0.75 in a disease-only KO subset; ungraded).
1 finding from 1 review
Retention of sealant (complete or partial retention) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
1 finding from 1 review
Chadwick 2005: one or more sealants fully/partially retained in 69 (31.2%) children at 12-30 months; Joshi 2019: at 12 months 75 (43.6%) teeth completely retained, 58 (33.7%) partially retained, 39 (22.7%) completely…
2 studies
GRADE not reported
Discomfort during treatment · Children (3-10 years) with dentine caries in primary molars
The reported estimate for treatment discomfort with the Hall Technique versus conventional restorations was inconclusive (ungraded).
1 finding from 1 review
RR 1.67 [0.65, 4.25]
2 studies
GRADE not reported
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; composite resin outperformed HVGIC in the review narrative.
1 finding from 1 review
Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy)
Preformed metal crowns had a low annual failure rate (2.5%) in primary molars after pulpotomy, but the evidence is of low quality (single high-risk-of-bias split-mouth RCT; not GRADE-rated).
2 findings from 1 review
Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucocele between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.02 [0.00, 1.09]
Studies not reported
Very low
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; cumulative failure rates were tabulated.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; cavity disinfectant did not affect success in the review narrative.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs1044956 (7:24854765; nearest gene(s) OSBPL3, NPVF) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs1044956 near OSBPL3, NPVF showed suggestive (not genome-wide significant) association with ECC (Z = 4.551, p = 5.35e-6); genetic association, ungraded.
2 findings from 1 review