What do systematic reviews say?

Recombinant human growth hormone vs placebo

• Recombinant human growth hormone for treating burns and donor sites 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 99 participants
  Low

Phototherapy vs control

• Phototherapy for treating pressure ulcers 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 32 participants
  Very low
• Phototherapy for treating pressure ulcers 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 8 participants
  Very low

Intervention not reported

The intervention showed no clear difference in oedema ‐ Day 1 Scale 1 to 4 (low certainty).

• Perioperative corticosteroids for preventing complications following facial plastic surgery 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 60 participants
  Low

Intervention not reported

The intervention showed no clear difference in ecchymosis ‐ Day 1 Scale 1 to 4 (low certainty).

• Perioperative corticosteroids for preventing complications following facial plastic surgery 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 60 participants
  Low

Continuous skin sutures vs interrupted skin sutures

It is very uncertain whether continuous skin sutures changes superficial surgical site infection compared with interrupted skin sutures (very low certainty).

• Continuous versus interrupted skin sutures for non‐obstetric surgery 2014 · Cochrane Headline outcomes only
  RR 0.73 [0.4, 1.33]
  4 studies · 602 participants
  Very low

Continuous skin sutures vs interrupted skin sutures

Continuous skin sutures may leads to lower superficial wound dehiscence compared with interrupted skin sutures (low certainty).

• Continuous versus interrupted skin sutures for non‐obstetric surgery 2014 · Cochrane Headline outcomes only
  RR 0.08 [0.02, 0.35]
  4 studies · 625 participants
  Low

Continuous skin sutures vs interrupted skin sutures

• Continuous versus interrupted skin sutures for non‐obstetric surgery 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 105 participants
  Very low

Subcutaneous closure vs no subcutaneous closure

It is very uncertain whether subcutaneous closure changes superficial surgical site infection compared with no subcutaneous closure (very low certainty).

• Subcutaneous closure versus no subcutaneous closure after non‐caesarean surgical procedures 2014 · Cochrane Headline outcomes only
  RR 0.84 [0.53, 1.33]
  6 studies · 815 participants
  Very low

Subcutaneous closure vs no subcutaneous closure

It is very uncertain whether subcutaneous closure changes superficial wound dehiscence compared with no subcutaneous closure (very low certainty).

• Subcutaneous closure versus no subcutaneous closure after non‐caesarean surgical procedures 2014 · Cochrane Headline outcomes only
  RR 0.56 [0.22, 1.41]
  2 studies · 215 participants
  Very low

Subcutaneous closure vs no subcutaneous closure

It is very uncertain whether subcutaneous closure changes deep wound dehiscence compared with no subcutaneous closure (very low certainty).

• Subcutaneous closure versus no subcutaneous closure after non‐caesarean surgical procedures 2014 · Cochrane Headline outcomes only
  RR 0.25 [0.03, 2.11]
  1 study · 60 participants
  Very low

Subcutaneous closure vs no subcutaneous closure

• Subcutaneous closure versus no subcutaneous closure after non‐caesarean surgical procedures 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 434 participants
  Very low

G‐CSF + standard treatment vs usual care

G‐CSF + standard treatment may leads to higher improvement of infection clinical and microbiological assessment compared with usual treatment (low certainty).

• Granulocyte‐colony stimulating factors as adjunctive therapy for diabetic foot infections 2013 · Cochrane Headline outcomes only
  RR 1.4 [1.06, 1.85]
  4 studies · 140 participants
  Low

G‐CSF + standard treatment vs usual care

G‐CSF + standard treatment may leads to lower need for surgery: Overall Surgical Interventions compared with usual treatment (low certainty).

• Granulocyte‐colony stimulating factors as adjunctive therapy for diabetic foot infections 2013 · Cochrane Headline outcomes only
  RR 0.37 [0.2, 0.68]
  5 studies · 167 participants
  Low

G‐CSF + standard treatment vs usual care

G‐CSF + standard treatment may leads to lower need for surgery: Amputation compared with usual treatment (low certainty).

• Granulocyte‐colony stimulating factors as adjunctive therapy for diabetic foot infections 2013 · Cochrane Headline outcomes only
  RR 0.41 [0.18, 0.95]
  5 studies · 167 participants
  Low

Fibrous‐hydrocolloid (hydrofibre) dressing vs basic wound contact dressing

Fibrous‐hydrocolloid (hydrofibre) dressing showed no clear difference in number of ulcers healed compared with basic wound contact dressing (moderate certainty).

• Hydrocolloid dressings for healing diabetic foot ulcers 2013 · Cochrane Headline outcomes only
  RR 1.01 [0.74, 1.38]
  2 studies · 229 participants
  Moderate

Fibrous‐hydrocolloid (hydrofibre) dressing vs basic wound contact dressing

• Hydrocolloid dressings for healing diabetic foot ulcers 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Fibrous‐hydrocolloid (hydrofibre) dressing vs basic wound contact dressing

• Hydrocolloid dressings for healing diabetic foot ulcers 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Hydrogel dressings vs basic wound contact dressing

Hydrogel dressings probably leads to higher number of ulcers healed compared with basic wound contact dressings (moderate certainty).

• Hydrogel dressings for healing diabetic foot ulcers 2013 · Cochrane Headline outcomes only
  RR 1.8 [1.27, 2.56]
  3 studies · 198 participants
  Moderate

Hydrogel dressings vs basic wound contact dressing

• Hydrogel dressings for healing diabetic foot ulcers 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 3 participants
  GRADE not reported

Hydrogel dressings vs Larval therapy

Hydrogel dressings showed no clear difference in number of ulcers healed compared with larval therapy (low certainty).

• Hydrogel dressings for healing diabetic foot ulcers 2013 · Cochrane Headline outcomes only
  RR 0.4 [0.08, 1.99]
  1 study · 140 participants
  Low