Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Intervention not reported

Weight (change during intervention) (mean ± SD) · Preterm neonates (< 37 0/7 weeks' gestation) fed exclusively with breast milk

The intervention showed no clear difference in weight (change during intervention) (mean ± SD) (low certainty).

1 finding from 1 review

Intervention not reported

Length (change during intervention) (mean ± SD) · Preterm neonates (< 37 0/7 weeks' gestation) fed exclusively with breast milk

The intervention showed no clear difference in length (change during intervention) (mean ± SD) (low certainty).

1 finding from 1 review

Intervention not reported

Head circumference (change during intervention) (mean ± SD) · Preterm neonates (< 37 0/7 weeks' gestation) fed exclusively with breast milk

The intervention showed no clear difference in head circumference (change during intervention) (mean ± SD) (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs another fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants
2 findings from 2 reviews · compare the 2 reviews

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (any definition) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE vs non‐fish oil LE (combined subgroups) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE… compared with non‐fish oil LE (low certainty).

1 finding from 1 review