Findings

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Evidence found and GRADE certainty

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Intervention not reported

Proteinuric pre‐eclampsia · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower proteinuric pre‐eclampsia (high certainty).

1 finding from 1 review

Intervention not reported

Any reported infant death (fetal, neonatal, or before hospital discharge · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower any reported infant death (fetal, neonatal, or before hospital… (high certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (before 37 weeks' gestation) · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower preterm birth (before 37 weeks' gestation) (high certainty).

1 finding from 1 review

Intervention not reported

Small‐for‐gestational age · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower small‐for‐gestational age (high certainty).

1 finding from 1 review

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review

Intervention not reported

Postpartum haemorrhage > 500 mL · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention showed no clear difference in postpartum haemorrhage > 500 mL (moderate certainty).

1 finding from 1 review

Intervention not reported

Placental abruption · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention showed no clear difference in placental abruption (moderate certainty).

1 finding from 1 review

Intervention not reported

Preterm birth < 34 weeks · women carrying twins, asymptomatic for PTL or PPROM

It is very uncertain whether the intervention changes preterm birth < 34 weeks (very low certainty).

1 finding from 1 review

Intervention not reported

Preterm birth < 37 weeks · singleton pregnancy with symptoms of PTL

It is very uncertain whether the intervention changes preterm birth < 37 weeks (very low certainty).

1 finding from 1 review

Active vs expectant management of the third stage of labour (all women)

Severe PPH (≥ 1000 mL) · all women who expected a vaginal birth at 24 weeks' gestation or later and their babies

It is very uncertain whether active changes severe primary PPH (clinically estimated or measured blood loss ≥… compared with expectant management of the third stage of labour (all women) (very low certainty).

1 finding from 1 review