Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Pre‐hospital vs in‐hospital thrombolysis

Adverse effects ‐ bleeding complications · participants with ST‐elevation myocardial infarction

Pre‐hospital showed no clear difference in adverse effects ‐ bleeding complications compared with in‐hospital thrombolysis (moderate certainty).

1 finding from 1 review

Intervention not reported

Recurrent pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone

The intervention probably leads to lower recurrent pericarditis Chest pain + (ECG changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

Symptom relief at 72 hours Patient reported

The intervention may leads to higher symptom relief at 72 hours Patient reported (low certainty).

1 finding from 1 review

Intervention not reported

Acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone

The intervention probably leads to lower acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic… (moderate certainty).

1 finding from 1 review

Intervention not reported

Total adverse effects Patient reported

The intervention showed no clear difference in total adverse effects Patient reported (low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects necessitating stop of therapy Patient reported

The intervention probably leads to higher adverse effects necessitating stop of therapy Patient reported (moderate certainty).

1 finding from 1 review

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Herbal medicines vs supportive therapy

Number of patients died of cardiac failure ‐ Astragaloside injection versus support therapy · patients with viral myocarditis

It is very uncertain whether herbal medicines changes number of patients died of cardiac failure: Astragaloside injection… compared with supportive therapy (very low certainty).

1 finding from 1 review

Intervention not reported

Number of patients with arrhythmia: Garlicin injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

It is very uncertain whether the intervention changes number of patients with arrhythmia: Garlicin injection plus… (very low certainty).

1 finding from 1 review