Doxycycline+Rifampicin vs Quinolones+Rifampicin
Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with quinolones+Rifampicin (low certainty).
- RR 1.8 [0.78, 4.18]4 studies · 296 participantsLow
Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with quinolones+Rifampicin (low certainty).
Doxycycline+Streptomycin showed no clear difference in total treatment failure compared with doxycycline+Gentamycin (low certainty).
It is very uncertain whether doxycycline+Streptomycin changes minor adverse drug reactions compared with doxycycline+Gentamycin (very low certainty).
The intervention showed no clear difference in parasitological cure ( (moderate certainty).
It is very uncertain whether the intervention changes parasitological cure ( (very low certainty).
It is very uncertain whether the intervention changes clinical improvement ( (very low certainty).
It is very uncertain whether the intervention changes gastrointestinal side effects ( (very low certainty).
It is very uncertain whether the intervention changes neurological side effects ( (very low certainty).
The intervention showed no clear difference in clinical improvement ( (moderate certainty).
The intervention probably leads to lower gastrointestinal side effects ( (moderate certainty).
The intervention may leads to lower neurological side effects ( (low certainty).
It is very uncertain whether the intervention changes parasitological cure ( (very low certainty).
It is very uncertain whether the intervention changes side effects: nausea/vomiting (very low certainty).
It is very uncertain whether the intervention changes side effects: headache (very low certainty).
ORS ≤ 270 mOsm/L (rice‐based) showed no clear difference in severe biochemical hyponatraemia(serum sodium < 125 mmol/L) compared with ORS ≥ 310 mOsm/L (glucose‐based) (low certainty).