Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,444 questions · 1,518 findings · 135 reviews · Infectious Diseases

No studies found 135 · 8.9%GRADE not reported 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%

Summary of findings: ACT vs CQ

Effective treatment of the blood stage parasite As assessed by: Recurrent parasitaemia before day 28 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: ACT showed no clear difference in effective treatment of the blood stage parasite As assessed by:… compared with CQ (high certainty).

1 finding from 1 review

Summary of findings: ACT vs CQ

Post‐treatment prophylaxis As assessed by: Recurrent parasitaemia between day 28 and day 42/56/63 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: ACT may leads to lower post‐treatment prophylaxis As assessed by: Recurrent parasitaemia… compared with CQ (low certainty).

1 finding from 1 review

Summary of findings: DHA‐P vs alternative ACTs

Effective treatment of the blood stage parasite As assessed by: Recurrent parasitaemia before day 28 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: DHA‐P probably leads to lower effective treatment of the blood stage parasite As assessed by:… compared with alternative ACTs (moderate certainty).

1 finding from 1 review

Summary of findings: DHA‐P vs alternative ACTs

Post treatment prophylaxis As assessed by: Recurrent parasitaemia between day 28 and 42 · Adults and children with uncomplicated P. vivax malaria

Summary of findings: DHA‐P may leads to lower post‐treatment prophylaxis As assessed by: Recurrent parasitaemia… compared with alternative ACTs (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause diarrhoea · People travelling from non‐endemic settings

The intervention showed no clear difference in all‐cause diarrhoea (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Clinical treatment failure (Persistent or worsening symptoms at the end of treatment) · patients symptomatic for NTS infection

It is very uncertain whether antibiotics changes clinical treatment failure (Persistent or worsening symptoms at the… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Diarrhoea · patients symptomatic for NTS infection

It is very uncertain whether antibiotics changes presence of diarrhoea at 2‐4 days compared with placebo or no treatment (very low certainty).

2 findings from 1 review