Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Statins vs placebo

Mean pressure gradient (mmHg) Better indicated by lower scores. · patients with aortic valve stenosis

Statin showed no clear difference in mean pressure gradient (mmHg) Better indicated by lower scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Valve area (cm2) Better indicated by higher scores. · patients with aortic valve stenosis

Statin showed no clear difference in valve area (cm2) Better indicated by higher scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Aortic jet velocity (m/s) · patients with aortic valve stenosis

Statin showed no clear difference in aortic jet velocity (m/s) compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Freedom from valve replacement · patients with aortic valve stenosis

Statin showed no clear difference in freedom from valve replacement compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

All cardiovascular death · patients with aortic valve stenosis

Statin showed no clear difference in death from cardiovascular cause compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Hospitalisation for any reason · patients with aortic valve stenosis

It is very uncertain whether statin changes hospitalisation for any reason compared with placebo (very low certainty).

1 finding from 1 review

Statins vs placebo

Adverse events ‐ Muscle pain · patients with aortic valve stenosis

Statin showed no clear difference in adverse events ‐ Muscle pain compared with placebo (moderate certainty).

1 finding from 1 review

Screening vs routine practice

Number of new diagnoses · vulnerable population: senior 65 years of age or older

Screening probably leads to higher number of new diagnoses: systematic screening vs routine practice compared with routine practice (moderate certainty).

2 findings from 1 review

Intervention not reported

Combined CVD death, non‐fatal MI, or non‐fatal stroke · patients in primary prevention of cardiovascular disease events

The intervention probably leads to lower combined CVD death, non‐fatal MI, or non‐fatal stroke (moderate certainty).

1 finding from 1 review

Intervention not reported

Combined coronary heart disease death or non‐fatal MI · patients in primary prevention of cardiovascular disease events

The intervention probably leads to lower combined coronary heart disease death or non‐fatal MI (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall mortality · patients in primary prevention of cardiovascular disease events

The intervention showed no clear difference in overall mortality (low certainty).

1 finding from 1 review

Intervention not reported

Non‐CVD mortality · patients in primary prevention of cardiovascular disease events

The intervention showed no clear difference in non‐CVD mortality (low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of therapy due to adverse effects · patients in primary prevention of cardiovascular disease events

It is very uncertain whether the intervention changes discontinuation of therapy due to adverse effects (very low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

All‐cause mortality · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

Total coronary heart disease · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in coronary heart disease (total) compared with no/opportunistic screening (low certainty).

1 finding from 1 review