Intervention not reported
- Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia 2016 · Cochrane Headline outcomes onlyno estimate extracted5 studies · 514 participantsLow
Statin showed no clear difference in mean pressure gradient (mmHg) Better indicated by lower scores. compared with placebo (low certainty).
Statin showed no clear difference in valve area (cm2) Better indicated by higher scores. compared with placebo (low certainty).
Statin showed no clear difference in aortic jet velocity (m/s) compared with placebo (low certainty).
Statin showed no clear difference in freedom from valve replacement compared with placebo (moderate certainty).
Statin showed no clear difference in death from cardiovascular cause compared with placebo (low certainty).
It is very uncertain whether statin changes hospitalisation for any reason compared with placebo (very low certainty).
Statin showed no clear difference in adverse events ‐ Muscle pain compared with placebo (moderate certainty).
Screening probably leads to higher number of new diagnoses: systematic screening vs routine practice compared with routine practice (moderate certainty).
Systematic screening showed no clear difference in number of new diagnoses compared with opportunistic screening (low certainty).
The intervention probably leads to lower combined CVD death, non‐fatal MI, or non‐fatal stroke (moderate certainty).
The intervention probably leads to lower combined coronary heart disease death or non‐fatal MI (moderate certainty).
The intervention showed no clear difference in overall mortality (low certainty).
The intervention showed no clear difference in non‐CVD mortality (low certainty).
It is very uncertain whether the intervention changes discontinuation of therapy due to adverse effects (very low certainty).
Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).
Systematic screening showed no clear difference in stroke (total) compared with no/opportunistic screening (low certainty).
Systematic screening showed no clear difference in coronary heart disease (total) compared with no/opportunistic screening (low certainty).