Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, earlier Demirjian stage A-D (vs F-H) increases odds of space closure (OR 3.11; low certainty).
1 finding from 1 review
Pattern of dental service utilisation and barriers · Adult residents of slums and non-slum urban settings of LMICs
Dental service use is low, episodic and pain-driven, with widespread self-care and cost/funding barriers; ungraded.
1 finding from 1 review
Utilisation was generally low, episodic and mostly problem/pain-driven (pain-driven visits ~70-99%); widespread self-care/home remedies were used as alternatives to professional care; lack of funds/cost, income, age,…
Studies not reported
GRADE not reported
Analgesic (painkiller) use · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
Single preoperative dose of systemic antibiotics (clindamycin 600… showed no clear difference in analgesic use compared with matched placebo, total chemo-mechanical debridement and root filling; GRADE not reported.
1 finding from 1 review
Child plaque (any plaque visible on any teeth) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Package of oral health education/promotion including oral hygiene… led to lower child plaque (any plaque visible on any teeth) compared with standard care; GRADE not reported.
1 finding from 1 review
White spot lesion incidence · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The self-etch primer system had higher WSL incidence than the conventional system, with certainty not graded.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether intralesional triamcinolone changes maximal mouth opening (interincisal distance) compared with intralesional triamcinolone plus salvianolic acid B (very low certainty).
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes primary caries prevention compared with chlorhexidine varnish (very low certainty).
1 finding from 1 review
Periodontal disease - SNP-based heritability · Japanese adults (present-study cohort)
SNP-based heritability of periodontal disease was low (h2=0.0519, SE 0.0182); ungraded.
1 finding from 1 review
Recurrence · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms)
Grape seed extract alters S. mutans biofilm morphology (2 studies; ungraded).
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
After removing Zhang 2006, the recessive model at BsmI(rs1544410) remained non-significant (OR 0.86); ungraded.
2 findings from 1 review
Mother gingival health (mild or moderate bone loss) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Dietary advice on how to achieve a healthy diet for infants… showed no clear difference in mother gingival health (mild or moderate bone loss) compared with standard care; GRADE not reported.
1 finding from 1 review
Frequency of mouth cleaning · Adult residents of slums and non-slum urban settings of LMICs
Twice-daily cleaning (recommended) is uncommon; most clean once, in the morning; ungraded.
1 finding from 1 review
White spot lesion rate and volume · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no significant difference in WSL rate or volume, with certainty not graded.
1 finding from 1 review
The WSL volume was lower in the Opal Seal group than in the Clearfil and Transbond XT groups, but there was no significant difference among the groups (p > 0.05).
1 study · 15 participants
GRADE not reported
Caries severity (d1 + mfs >= 5) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Advice about a healthy diet (including breastfeeding promotion and… led to lower caries severity (d1 + mfs >= 5) compared with standard care; GRADE not reported.
1 finding from 1 review
Salivary IL-8 level (pg/mL) · Children and young adults (3-25 years)
Salivary IL-8 levels are higher in children and young adults with active dental caries than in controls but the difference is not statistically significant (SMD 57.20 pg/mL, 95% CI -18.60 to 133.00; 7 studies); ungraded.
1 finding from 1 review
Enamel demineralization / white spot lesion prevention (DIAGNOdent, enamel mineral content) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two small RCTs gave inconsistent results for TiO2-modified adhesives/composites on enamel demineralization (one favorable on DIAGNOdent, one no difference in mineral content); ungraded.
1 finding from 1 review
Oral cancer risk · People with and without more than 15 missing teeth
More than 15 missing teeth was associated with higher odds of oral cancer.
1 finding from 1 review
OR 1.91 [1.01, 3.62]
5 studies
GRADE not reported
Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review