High salivary P. gingivalis (over 10^4 CFU/ml) · adults
Periodontitis was associated with higher odds of detectable high-level salivary P. gingivalis (OR 3.38).
1 finding from 1 review
OR 3.38 [1.46, 7.83]
2 studies
GRADE not reported
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar)
In the maxilla, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 4.78; low certainty).
1 finding from 1 review
Depression · People with temporomandibular disorders (TMD)
Occlusal splint led to lower depression compared with no treatment or placebo (non-occlusal or transparent-foil placebo…; GRADE not reported.
1 finding from 1 review
Enamel resistance to demineralization (microhardness / lesion depth) · Human enamel adjacent to restorations or in pits and fissures (in situ / ex vivo)
Er:YAG laser showed a mixed and limited effect on enamel resistance to demineralization: feasible for controlling progression around restorations but not preventing caries formation, and ineffective in pits and fissures (ungraded, 2 ex-vivo studies, no pooled estimate).
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Gao 2019 noted that "arrested lesions were stained black" (reported with no associated data). No other adverse effects observed, and no reports from parents of systemic disease.
1 study · 1070 participants
Very low
Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) showed no clear difference in wits appraisal compared with facemask with alternating rapid maxillary expansion and constriction…; GRADE not reported.
1 finding from 1 review
Dental caries · Adults in case-control studies (oral cancer patients vs healthy controls)
The DMFT index was significantly higher in oral cancer patients than controls (SMD 0.65, 95% CI 0.12-1.18); ungraded.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether jaw opening exercises alone changes maximal mouth opening (interincisal distance) compared with ultrasound plus jaw opening exercises (very low certainty).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review
Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)
Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.
1 finding from 1 review
Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)
Occlusal splint showed no clear difference in participant satisfaction or quality of life compared with acupuncture; GRADE not reported.
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Biofilm morphological changes · Streptococcus mutans (in vitro cultures and biofilms)
Cranberry extract alters S. mutans biofilm morphology/architecture (4 studies; ungraded).
1 finding from 1 review
Cranberry treatment disrupted biofilm integrity with agglutination/cell degradation at higher concentrations (Singhal), reduced polymicrobial biomass 38% at 96 h (Philip 2019), produced defective accumulation and…
4 studies
GRADE not reported
Intervention not reported
Spontaneous space closure
1 finding from 1 review
OR >100.00
1 study
GRADE not reported
Change in probing pocket depth (PPD) · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… showed no clear difference in change in probing depth (PD/PPD) compared with submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT; GRADE not reported.
1 finding from 1 review
Muscle pain when chewing · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes muscle pain when chewing compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Surgical miniplates with facemask showed no clear difference in ANB compared with surgical miniplates with Class III elastics; GRADE not reported.
1 finding from 1 review
Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review