Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
3 findings from 1 review
No studies measured this outcome for root surfaces
0 studies
No studies found
Peto OR 44.22 [33.12, 59.04]
1 study · 663 participants
Very low
OR 1.08 [0.52, 2.23]
1 study · 128 participants
Very low
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
In one trial, nano-silver fluoride arrested more surfaces than SDF (OR 0.52 favoring the comparator; ungraded subgroup).
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
pH drop / acidogenicity buffering · Streptococcus mutans (in vitro cultures and biofilms)
Cranberry extract reduces S. mutans acidogenicity / glycolytic pH drop in vitro (5 studies; ungraded).
1 finding from 1 review
Cranberry PAC buffered acidogenesis: final pH 5.6 vs 5.2 control (Koo), lactic acid reduced 44% (Philip 2019) and 46% at 500 ug/mL (Philip 2019 EJOS), final pH 4.7-4.9 vs 3.7 control (Duarte), and disrupted glycolytic…
5 studies
GRADE not reported
Dental pain or sensitivity · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes dental pain or sensitivity compared with fluoride varnish (very low certainty).
1 finding from 1 review
Intervention not reported
Correlation between teledentistry and clinical caries assessment
1 finding from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
It is very uncertain whether fluoride toothpaste less than 1000 ppm (lower concentration) changes fluorosis (percentage prevalence in permanent teeth) compared with fluoride toothpaste 1000 ppm or more (higher concentration) (very low certainty).
2 findings from 1 review
Dental caries · Primary school children in Ethiopia
A high intake of sweets was associated with higher odds of dental caries (OR 2.71, 95% CI 1.968-3.451; ungraded).
1 finding from 1 review
OR 2.71 [1.968, 3.451]
5 studies
GRADE not reported
Gtf activity · Streptococcus mutans (in vitro cultures and biofilms)
One study reported grape seed extract inhibits S. mutans Gtf activity (ungraded).
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Surgical miniplates with facemask showed no clear difference in overjet compared with surgical miniplates with Class III elastics; GRADE not reported.
1 finding from 1 review
Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Across three small non-randomized studies, fluoride-releasing primers (Opal Seal, Clearfil) showed no consistent clinical advantage over conventional primers in preventing white spot lesions (ungraded).
1 finding from 1 review
Calcium and phosphate ion release · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, an n-ACP-containing adhesive significantly increased calcium and phosphate ion release up to 42 days in a single study (ungraded).
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
The number of missing teeth (per tooth) was not significantly associated with oral cancer (OR 0.96, 95% CI 0.92-1.01); ungraded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence in children
1 finding from 1 review
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Pentoxifylline led to lower difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
It is very uncertain whether started toothbrushing with fluoride toothpaste before 24 months… changes fluorosis (percentage prevalence in permanent teeth) compared with started after 24 months (later start) (very low certainty).
1 finding from 1 review
Salivary S. mutans level · Humans with salivary bacteria measured
Salivary F. nucleatum and Actinobacillus levels were not associated with a clear difference.
1 finding from 1 review
OR 2.39 [1.00, 5.71]
1 study
GRADE not reported
Intervention not reported
Change in prevalence of salivary Streptococcus sobrinus
1 finding from 1 review
Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)
One study reported high antioxidant capacity of grape seed extract (ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
Breastfeeding for <18 vs ≥18 months was associated with significantly fewer caries (RR 0.41, 95% CI 0.18-0.92; substantial heterogeneity; ungraded).
2 findings from 1 review