Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,281 questions · 1,361 findings · 120 reviews · Developmental, Psychosocial and Learning Problems

No studies found 286 · 21%GRADE not reported 61 · 4.5%Very low 381 · 28%Low 381 · 28%Moderate 228 · 16.8%High 24 · 1.8%

Probiotics vs placebo

Relief of pain · Children with recurrent abdominal pain

Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Different… compared with placebo (moderate certainty).

2 findings from 1 review

Probiotics vs placebo

Improvement in pain: 0 to 3 months' postintervention Subgroup (irritable bowel syndrome) Different measures were used to assess improvement in pain, as above. · Children with recurrent abdominal pain

Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Subgroup… compared with placebo (moderate certainty).

1 finding from 1 review

Fibre vs placebo

Improvement in pain: 0 to 3 months' postintervention Improvement in pain was defined and measured differently in the 2 included studies: using a "stomach ache diary" and the Faces Pain Scale (Bieri 1990). · Children with recurrent abdominal pain

Fibre showed no clear difference in improvement in pain: 0 to 3 months' postintervention Improvement in… compared with placebo (low certainty).

1 finding from 1 review

High‐dose methylphenidate vs placebo

Inattention Measured using SNAP‐IV inattention subscale (range 0 to 27) · Children aged 6 to 18 years with ASD
2 findings from 1 review