Findings

What do systematic reviews say?

266 questions · 274 findings · 25 reviews · Movement Disorders

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No studies found 13 · 4.7%GRADE not reported 7 · 2.6%Very low 66 · 24.1%Low 66 · 24.1%Moderate 87 · 31.8%High 35 · 12.8%

Deep brain stimulation vs sham stimulation

Dystonia‐specific improvement · adults with generalised or segmental dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Deep brain stimulation vs sham stimulation

Health‐related quality of life (mental) · adults with cervical dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Deep brain stimulation vs sham stimulation

Functional capacity · adults with cervical dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Deep brain stimulation vs sham stimulation

Emotional Assessment · adults with cervical dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Low

Deep brain stimulation vs sham stimulation

Adverse events · adults with dystonia (generalised, segmental, and cervical)

It is very uncertain whether deep brain stimulation changes adverse Events compared with sham stimulation (very low certainty).

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
RR 1.58 [0.98, 2.54]
2 studies · 102 participants
Very low

Deep brain stimulation vs sham stimulation

Tolerability · adults with dystonia (generalised, segmental, and cervical)

It is very uncertain whether deep brain stimulation changes tolerability compared with sham stimulation (very low certainty).

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
RR 1.86 [0.16, 21.57]
2 studies · 102 participants
Very low

Deep brain stimulation vs sham stimulation

Subjective Evaluation of Clinical Status · adults with generalised or segmental dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Deep brain stimulation vs sham stimulation

Quality of Life Assessment · adults with generalised or segmental dystonia

2 findings from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Low
Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

Deep brain stimulation vs sham stimulation

Functional capacity · adults with generalised or segmental dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

Deep brain stimulation vs sham stimulation

Emotional Assessment · adults with generalised or segmental dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Deep brain stimulation vs sham stimulation

Dystonia‐specific symptoms ( · adults with cervical dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Low

Deep brain stimulation vs sham stimulation

Clinical status( · adults with cervical dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Low

Deep brain stimulation vs sham stimulation

Physical functioning component of health‐related quality of life, measured using various scales · adults with cervical dystonia

1 finding from 1 review

Deep brain stimulation for dystonia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Botulinum toxin vs placebo

Severity of motor tics (measured by videotape of tic count) · Tourette's syndrome with motor and phonic tics

1 finding from 1 review

Botulinum toxin for motor and phonic tics in Tourette's syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Botulinum toxin vs placebo

Severity of phonic tics · Tourette's syndrome with motor and phonic tics

The review found no eligible studies for this question.

1 finding from 1 review

Botulinum toxin for motor and phonic tics in Tourette's syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Botulinum toxin vs placebo

Premonitory Urge (treated tics) · Tourette's syndrome with motor and phonic tics

1 finding from 1 review

Botulinum toxin for motor and phonic tics in Tourette's syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Botulinum toxin vs placebo

Sensory tics · Tourette's syndrome with motor and phonic tics

The review found no eligible studies for this question.

1 finding from 1 review

Botulinum toxin for motor and phonic tics in Tourette's syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Botulinum toxin vs placebo

Adverse events · Tourette's syndrome with motor and phonic tics

1 finding from 1 review

Botulinum toxin for motor and phonic tics in Tourette's syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Botulinum toxin vs placebo

Development of immunoresistance against botulinum toxin · Tourette's syndrome with motor and phonic tics

The review found no eligible studies for this question.

1 finding from 1 review

Botulinum toxin for motor and phonic tics in Tourette's syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Functional disability ( · people with essential tremor

1 finding from 1 review

Topiramate for essential tremor 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 223 participants
Very low