Cochrane · systematic review · CD012405
Deep brain stimulation for dystonia
Rodrigues, FB, Duarte, GS, Prescott, D, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Movement DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 50%Low 7 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Deep brain stimulation compared to sham stimulation in generalised or segmental dystonia
Population: adults with generalised or segmental dystonia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dystonia‐specific improvement Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias |
Subjective Evaluation of Clinical Status Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 37 participants | Low Downgraded: risk of bias |
Quality of Life Assessment Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 33 participants | Low Downgraded: risk of bias |
Quality of Life Assessment Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 33 participants | Very low Downgraded: risk of bias |
Functional Capacity Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 39 participants | Low Downgraded: risk of bias |
Emotional Assessment Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias |
Deep brain stimulation compared to sham stimulation in cervical dystonia
Population: adults with cervical dystonia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dystonia‐specific symptoms ( Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 62 participants | Low Downgraded: risk of bias |
Clinical status( Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 62 participants | Low Downgraded: risk of bias |
Quality of Lifeusing SF‐36: physical functioning( Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 62 participants | Very low Downgraded: risk of bias |
Quality of Life Assessmentusing SF‐36: mental health( Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 62 participants | Very low Downgraded: risk of bias |
Functional capacity Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 62 participants | Very low Downgraded: risk of bias |
Emotional assessment Deep brain stimulation vs sham stimulation | no estimate extracted | 1 study · 62 participants | Low Downgraded: risk of bias |
Deep brain stimulation compared to sham stimulation in dystonia
Population: adults with dystonia (generalised, segmental, and cervical)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Adverse Events Deep brain stimulation vs sham stimulation | RR 1.58 [0.98, 2.54] | 2 studies · 102 participants | Very low Downgraded: risk of bias |
Tolerability Deep brain stimulation vs sham stimulation | RR 1.86 [0.16, 21.57] | 2 studies · 102 participants | Very low Downgraded: risk of bias |