Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,281 questions · 1,361 findings · 120 reviews · Developmental, Psychosocial and Learning Problems

No studies found 286 · 21%GRADE not reported 61 · 4.5%Very low 381 · 28%Low 381 · 28%Moderate 228 · 16.8%High 24 · 1.8%

Desipramine (antidepressant) vs placebo

ADHD symptom‐related behavior Measured by standardized rating scales: Child Behaviour Checklist, Gordon Diagnostic System, Clinical Evaluation of Language Function, Matching Familial Figures Test, Porteus Maze Test, Restricted Academic Test, ADHD ... · children with ADHD and comorbid tic disorders
1 finding from 1 review

Desipramine (antidepressant) vs placebo

Tic severity Measured by standardized rating scales: Yale Global Tic Severity Scale, Tourette Syndrome Severity Scale, Hopkins Motor/Vocal Scale; ADHD Parent Linear Analogue Scale · children with ADHD and comorbid tic disorders
1 finding from 1 review

Intervention not reported

Autism symptom severity Measured by: parent‐reported autism symptoms on standardised autism screening and diagnostic instruments (lower scores indicate less severe autism symptoms) · patients with young children (less than six years old) with autism spectrum disorders (ASD)
1 finding from 1 review

Intervention not reported

Communication and language skills: expressive language Measured by: standardized measures of expressive language (higher scores indicate better expressive language skills) · patients with young children (less than six years old) with autism spectrum disorders (ASD)
1 finding from 1 review

Intervention not reported

Communication and language skills: receptive language Measured by: standardized measures of receptive language (higher scores indicate better receptive language skills) · patients with young children (less than six years old) with autism spectrum disorders (ASD)
1 finding from 1 review