Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,060 questions · 1,105 findings · 84 reviews · Metabolic and Endocrine Disorders

No studies found 434 · 39.3%GRADE not reported 32 · 2.9%Very low 246 · 22.3%Low 237 · 21.4%Moderate 132 · 11.9%High 24 · 2.2%

Total or near‐total thyroidectomy vs subtotal thyroidectomy

a)Goitre recurrence b)Re‐intervention due to goitre recurrence

Total or near‐total thyroidectomy probably leads to lower a)Goitre recurrence b)Re‐intervention due to goitre recurrence compared with subtotal thyroidectomy (moderate certainty).

1 finding from 1 review

Total or near‐total thyroidectomy vs subtotal thyroidectomy

Adverse events: a) Permanent recurrent laryngeal nerve palsy b) Permanent hypoparathyroidism

Total or near‐total thyroidectomy showed no clear difference in adverse events: a) Permanent recurrent laryngeal nerve palsy b)… compared with subtotal thyroidectomy (low certainty).

1 finding from 1 review

Total thyroidectomy vs subtotal thyroidectomy

R ate of recurrent hyperthyroidism [measured by thyroid function tests]

Total thyroidectomy probably leads to lower rate of recurrent hyperthyroidism [measured by thyroid function tests] compared with subtotal thyroidectomy (moderate certainty).

2 findings from 1 review

Total thyroidectomy vs subtotal thyroidectomy

Permanent recurrent laryngeal nerve palsy [patient reported, confirmation by laryngoscopy]

Total thyroidectomy showed no clear difference in permanent recurrent laryngeal nerve palsy [patient reported,… compared with bilateral subtotal thyroidectomy (low certainty).

2 findings from 1 review

Total thyroidectomy vs subtotal thyroidectomy

Permanent hypocalcaemia/hypoparathyroidism [measured by serum calcium levels]

Total thyroidectomy showed no clear difference in permanent hypocalcaemia/hypoparathyroidism [measured by serum… compared with bilateral subtotal thyroidectomy (low certainty).

2 findings from 1 review