Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

729 questions · 775 findings · 58 reviews · Bone, Joint and Muscle Trauma

No studies found 166 · 21.4%GRADE not reported 24 · 3.1%Very low 356 · 45.9%Low 162 · 20.9%Moderate 47 · 6.1%High 20 · 2.6%

Summary of findings: whole‐body cryotherapy (WBC) vs control (no WBC or passive rest)

Adverse events · physically‐active adults partaking in exercise designed to produce delayed onset muscle soreness (most trial participants were male)

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

VISA‐A (score 0 to 100; 100 = no problems) After 3 months (6 to 12 months) · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

Summary of findings: Injection therapies showed no clear difference in VISA‐A (score 0 to 100; 100 = no problems) At 6 weeks compared with placebo or no injection control (low certainty).

3 findings from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Adverse events At final · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes adverse events At final compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Pain (VAS; score 0 to 100; 0 = no pain) · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes pain (VAS; score 0 to 100; 0 = no pain) compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Return to sports At final · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes return to sports At final compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Summary of findings: Injection therapies vs placebo or no injection control

Patient satisfaction Number of satisfied patients · individuals with an investigator‐reported diagnosis of Achilles tendinopathy (or related terminology, e.g. tendinitis). We excluded trials…

It is very uncertain whether summary of findings: Injection therapies changes patient satisfaction (number of participants satisfied with their… compared with placebo or no injection control (very low certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Hip Fracture · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining new hip fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

New fractures · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus… compared with control or placebo (low certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with renal disease (calculi or insufficiency) ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to higher persons with renal disease (calculi or insufficiency) ‐ Vitamin D… compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Intervention not reported

Hip fractures at 1 year older people living in the community · older people

The intervention showed no clear difference in hip fractures at 1 year older people living in the community (moderate certainty).

1 finding from 1 review

Intervention not reported

Hip fractures at 1 year older people living in institutions · older people

The intervention showed no clear difference in hip fractures at 1 year older people living in institutions (moderate certainty).

1 finding from 1 review

Intervention not reported

Pelvic fractures at 1 year · older people

The intervention showed no clear difference in pelvic fractures at 1 year (low certainty).

1 finding from 1 review

Intervention not reported

Other fractures at 1 year (excluding pelvis) · older people

The intervention showed no clear difference in other fractures at 1 year (excluding pelvis) (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of falls per 1000 people at 1 year · older people

The intervention showed no clear difference in number of falls per 1000 people at 1 year (moderate certainty).

1 finding from 1 review