Any adverse event by 6 weeks · people with agitation in dementia
Valproate preparations may leads to higher any adverse event by 6 weeks compared with placebo (low certainty).
1 finding from 1 review
Serious adverse events by 6 weeks · people with agitation in dementia
It is very uncertain whether valproate preparations changes serious adverse events by 6 weeks compared with placebo (very low certainty).
1 finding from 1 review
Duration of delirium Days · delirious patients
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality · delirious patients
Typical showed no clear difference in mortality compared with atypical antipsychotics (moderate certainty).
1 finding from 1 review
Length of hospital stay · delirious patients
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · delirious patients
It is very uncertain whether typical changes adverse Effects ‐ EPS compared with atypical antipsychotics (very low certainty).
1 finding from 1 review
Severity of delirium · delirious patients
1 finding from 1 review
Delirium resolution DRS, DRS‐R981 · delirious patients
It is very uncertain whether antipsychotics changes delirium resolution DRS, DRS‐R981 compared with nonantipsychotics or placebo (very low certainty).
1 finding from 1 review
All‐cause mortality · delirious patients
Antipsychotics showed no clear difference in mortality compared with nonantipsychotics or placebo (moderate certainty).
1 finding from 1 review
Length of hospital stay · delirious patients
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · delirious patients
It is very uncertain whether antipsychotics changes adverse Effects ‐ EPS Extrapyramidal Symptom Rating Scale, or not… compared with nonantipsychotics or placebo (very low certainty).
1 finding from 1 review
Duration of delirium Days · delirious patients
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Delirium resolution DRS, DRS‐R981 · delirious patients
Typical showed no clear difference in delirium resolution DRS, DRS‐R981 compared with atypical antipsychotics (moderate certainty).
1 finding from 1 review
Severity of delirium · delirious patients
1 finding from 1 review
Success of withdrawal from antipsychotics · older people with dementia who had been taking an antipsychotic drug for at least 3 months
Discontinuation may leads to lower success of withdrawal from antipsychotics compared with continuation of antipsychotic medication (low certainty).
1 finding from 1 review
Behavioural and psychological symptoms · older people with dementia who had been taking an antipsychotic drug for at least 3 months
1 finding from 1 review
Adverse events · older people with dementia who had been taking an antipsychotic drug for at least 3 months
1 finding from 1 review
QoL · older people with dementia who had been taking an antipsychotic drug for at least 3 months
1 finding from 1 review
Cognitive function · older people with dementia who had been taking an antipsychotic drug for at least 3 months
1 finding from 1 review
Use of physical restraints · older people with dementia who had been taking an antipsychotic drug for at least 3 months
1 finding from 1 review