Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

475 questions · 487 findings · 49 reviews · Breast Cancer

No studies found 44 · 9%GRADE not reported 14 · 2.9%Very low 108 · 22.2%Low 128 · 26.3%Moderate 107 · 22%High 86 · 17.7%

Early shoulder mobilising exercises vs delayed shoulder mobilising exercises

Lymphoedema ‐ medium term · patients at risk for secondary upper limb lymphoedema after breast cancer treatment

It is very uncertain whether early shoulder mobilising exercises changes lymphoedema ‐ medium term compared with delayed shoulder mobilising exercises (very low certainty).

1 finding from 1 review

Intervention not reported

Overall survival · patients with HER2‐positive metastatic breast cancer

The intervention probably leads to lower overall survival (moderate certainty).

1 finding from 1 review

Intervention not reported

Progression‐free survival · patients with HER2‐positive metastatic breast cancer

The intervention probably leads to lower progression‐free survival (moderate certainty).

1 finding from 1 review

Intervention not reported

Congestive heart failure · patients with HER2‐positive metastatic breast cancer

The intervention probably leads to higher congestive heart failure (moderate certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps vs no‐fibrin

Incidence of postoperativeseromaRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in incidence of postoperativeseromaRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps vs no‐fibrin

PostoperativecomplicationsRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in postoperativecomplicationsRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Intervention not reported

Overall survival (OS) · HER2‐positive early breast cancer patients

The intervention leads to lower overall survival (OS) (high certainty).

1 finding from 1 review

Intervention not reported

Disease free survival (DFS) · HER2‐positive early breast cancer patients

The intervention leads to lower disease free survival (DFS) (high certainty).

1 finding from 1 review

Intervention not reported

Congestive heart failure (CHF) · HER2‐positive early breast cancer patients

The intervention leads to higher congestive heart failure (CHF) (high certainty).

1 finding from 1 review

Intervention not reported

Left ventricular ejection fraction decline (LVEF) · HER2‐positive early breast cancer patients

The intervention probably leads to higher left ventricular ejection fraction decline (LVEF) (moderate certainty).

1 finding from 1 review