Cochrane · systematic review · CD009765

Conservative interventions for preventing clinically detectable upper‐limb lymphoedema in patients who are at risk of developing lymphoedema after breast cancer therapy

Stuiver, MM, ten Tusscher, MR, Agasi‐Idenburg, CS, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library

Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
15
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 10 · 66.7%Low 4 · 26.7%Moderate 1 · 6.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Early physiotherapy including MLD for patients at risk for secondary upper limb lymphoedema after breast cancer treatment

Population: patients at risk for secondary upper limb lymphoedema after breast cancer treatment
7 questions
OutcomeEffectEvidenceStatus / GRADE
Time to event (Lymphoedema) volumetry
no estimate extracted2 studies · 270 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Lymphoedema ‐ short term
no estimate extracted2 studies · 226 participantsVery low
Downgraded: risk of bias, imprecision
Lymphoedema ‐ medium term
no estimate extracted4 studies · 385 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Shoulder range of motion for abduction ‐ short term
no estimate extracted2 studies · 183 participantsLow
Downgraded: risk of bias, imprecision
Shoulder range of motion for forward flexion ‐ short term
no estimate extracted3 studies · 183 participantsLow
Downgraded: risk of bias, imprecision
Shoulder range of motion for abduction ‐ medium term
no estimate extracted3 studies · 183 participantsVery low
Downgraded: risk of bias, imprecision
Shoulder range of motion for forward flexion ‐ medium term
no estimate extracted3 studies · 183 participantsVery low
Downgraded: risk of bias, imprecision

Early shoulder mobilising exercises compared to delayed shoulder mobilising exercises for patient surgically treated for breast cancer

Population: patients at risk for secondary upper limb lymphoedema after breast cancer treatment
7 questions
OutcomeEffectEvidenceStatus / GRADE
Lymphoedema ‐ medium term
Early shoulder mobilising exercises vs delayed shoulder mobilising exercises
RR 1.69 [0.94, 3.01]3 studies · 378 participantsVery low
Downgraded: risk of bias, imprecision
Shoulder range of motion for abduction ‐ short term
Early shoulder mobilising exercises vs delayed shoulder mobilising exercises
no estimate extracted2 studies · 262 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Shoulder range of motion for abduction ‐ medium term
Early shoulder mobilising exercises vs delayed shoulder mobilising exercises
no estimate extracted3 studies · 378 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Shoulder range of motion for forward flexion ‐ short term
Early shoulder mobilising exercises vs delayed shoulder mobilising exercises
no estimate extracted2 studies · 262 participantsLow
Downgraded: risk of bias, imprecision, inconsistency
Shoulder range of motion for forward flexion ‐ medium term
Early shoulder mobilising exercises vs delayed shoulder mobilising exercises
no estimate extracted3 studies · 321 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Shoulder range of motion for external rotation ‐ medium term
Early shoulder mobilising exercises vs delayed shoulder mobilising exercises
no estimate extracted3 studies · 378 participantsVery low
Downgraded: risk of bias, imprecision
Shoulder range of motion for internal rotation ‐ medium term
Early shoulder mobilising exercises vs delayed shoulder mobilising exercises
no estimate extracted3 studies · 378 participantsLow
Downgraded: risk of bias, imprecision

Progressive resistance exercise for patients at risk for secondary upper limb lymphoedema after breast cancer treatment

Population: patients at risk for secondary upper limb lymphoedema after breast cancer treatment
1 question
OutcomeEffectEvidenceStatus / GRADE
Lymphoedema Volumetry
RR 0.58 [0.3, 1.13]2 studies · 351 participantsModerate
Downgraded: risk of bias, imprecision