Proportion of participants with one or more serious adverse events · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes proportion of participants with one or more serious adverse events compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Adverse events considered non‐serious (penicillin versus doxycycline) · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes proportion of participants with one or more adverse events… compared with placebo or no intervention (very low certainty).
1 finding from 1 review
General behaviour: all parallel‐group trials and first‐period cross‐over trials General behaviour rating scales (Teacher‐rated) · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes general behaviour: all parallel‐group trials and first‐period… compared with placebo or no intervention (very low certainty).
1 finding from 1 review
QoL · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes quality of life (parent‐rated) compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Seizure freedom · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · people with focal epilepsy
Immunomodulatory interventions probably leads to higher 50% or greater reduction in seizure frequency ‐ ITT analysis compared with placebo (moderate certainty).
1 finding from 1 review
Adverse events of glucocorticoids and immunosuppressive drugs · people with focal epilepsy
Immunomodulatory interventions may leads to higher adverse events of glucocorticoids and immunosuppressive drugs compared with placebo (low certainty).
1 finding from 1 review
Treatment withdrawal · people with focal epilepsy
Immunomodulatory interventions may leads to higher treatment withdrawal compared with placebo (low certainty).
1 finding from 1 review
Allergic reaction · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cognitive effects · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Time required for successful intubation · neonates (0 to 28 days of age) who needed tracheal intubation
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Number of intubation attempts · neonates (0 to 28 days of age) who needed tracheal intubation
1 finding from 1 review
no estimate extracted
Studies not reported
Low
First‐attempt success rate · neonates (0 to 28 days of age) who needed tracheal intubation
Videolaryngoscopy may leads to higher success rate at first attempt compared with conventional direct laryngoscopy (low certainty).
1 finding from 1 review
RR 1.24 [1.13, 1.37]
Studies not reported
Low
Non‐airway‐related adverse effects: desaturation or bradycardia episodes, or both · neonates (0 to 28 days of age) who needed tracheal intubation
It is very uncertain whether videolaryngoscopy changes non‐airway‐related adverse effects: desaturation or bradycardia… compared with conventional direct laryngoscopy (very low certainty).
1 finding from 1 review
RR 0.94 [0.38, 2.3]
Studies not reported
Very low
Non‐airway‐related adverse effects: lowest saturations during intubation · neonates (0 to 28 days of age) who needed tracheal intubation
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Airway‐related adverse effects: airway trauma · neonates (0 to 28 days of age) who needed tracheal intubation
Videolaryngoscopy probably leads to lower airway‐related adverse effects: airway trauma compared with conventional direct laryngoscopy (moderate certainty).
1 finding from 1 review
RR 0.21 [0.05, 0.79]
Studies not reported
Moderate
CTS symptoms (Boston CTS questionnaire) ‐ short‐term improvement: < 3 monthsScale: 1 to 5, higher is worse · carpal tunnel syndrome
1 finding from 1 review
CTS symptoms (Boston CTS questionnaire) ‐ long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · carpal tunnel syndrome
1 finding from 1 review
Function (Boston CTS questionnaire) ‐ Long‐term improvement: > 3 monthsScale: 1 to 5, higher is worse · carpal tunnel syndrome
1 finding from 1 review