Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,444 questions · 1,518 findings · 135 reviews · Infectious Diseases

No studies found 135 · 8.9%GRADE not reported 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%

Effect of LF‐LAM vs no LF‐LAM on mortality and tuberculosis treatment initiation

Mortality at 8 weeks · adults living with HIV

Effect of LF‐LAM probably leads to lower mortality at 8 weeks compared with no LF‐LAM on mortality and tuberculosis treatment initiation (moderate certainty).

1 finding from 1 review

Effect of LF‐LAM vs no LF‐LAM on mortality and tuberculosis treatment initiation

People started on tuberculosis treatment · adults living with HIV

Effect of LF‐LAM showed no clear difference in people started on tuberculosis treatment compared with no LF‐LAM on mortality and tuberculosis treatment initiation (moderate certainty).

2 findings from 1 review

Effect of LF‐LAM vs no LF‐LAM on mortality and tuberculosis treatment initiation

Mortality at 6 months · adults living with HIV

Effect of LF‐LAM showed no clear difference in mortality at 6 months compared with no LF‐LAM on mortality and tuberculosis treatment initiation (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Intervention not reported

Relapsec · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention probably leads to higher relapsec (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea lasting ≥ 48 hours · children and adults with acute infectious diarrhoea

The intervention showed no clear difference in diarrhoea lasting ≥ 48 hours (moderate certainty).

1 finding from 1 review

Intervention not reported

Mean duration of diarrhoea (hours) · children and adults with acute infectious diarrhoea
1 finding from 1 review

Intervention not reported

Treatment failure day‐28 PCR‐adjusted(PP population) · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in treatment failure day‐28 PCR‐adjusted(PP population) (low certainty).

1 finding from 1 review

Intervention not reported

Treatment failureday‐28 PCR‐adjusted(ITT population) · children aged 14 years or younger with uncomplicated P falciparum malaria

The intervention showed no clear difference in treatment failureday‐28 PCR‐adjusted(ITT population) (low certainty).

1 finding from 1 review