What do systematic reviews say?

Prednisone plus azathioprine vs prednisone

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Nicotinamide plus tetracycline vs prednisone

It is very uncertain whether nicotinamide plus tetracycline changes disease control: complete response at 8 weeks: excluding dropouts compared with prednisone (very low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 2.5 [0.37, 16.89]
  1 study · 18 participants
  Very low

Nicotinamide plus tetracycline vs prednisone

It is very uncertain whether nicotinamide plus tetracycline changes mortality at 6 months compared with prednisone (very low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.18 [0.01, 3.85]
  1 study · 18 participants
  Very low

Nicotinamide plus tetracycline vs prednisone

The review found no eligible studies for this question.

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Clobetasol propionate cream vs prednisone

Clobetasol propionate cream showed no clear difference in mortality at 1 year compared with oral prednisone (low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.73 [0.53, 1.01]
  1 study · 341 participants
  Low

Nicotinamide plus tetracycline vs prednisone

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Methylprednisolone plus azathioprine vs methylprednisolone plus dapsone

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 54 participants
  Very low

Methylprednisolone plus azathioprine vs methylprednisolone plus dapsone

It is very uncertain whether methylprednisolone plus azathioprine changes mortality at 1 year compared with methylprednisolone plus dapsone (very low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.33 [0.04, 3.01]
  1 study · 54 participants
  Very low

Methylprednisolone plus azathioprine vs methylprednisolone plus dapsone

The review found no eligible studies for this question.

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methylprednisolone plus azathioprine vs methylprednisolone plus dapsone

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Clobetasol propionate cream vs prednisone

The review found no eligible studies for this question.

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Clobetasol propionate cream vs prednisone

Clobetasol propionate cream may leads to lower adverse events: severe complications at day 21 compared with oral prednisone (low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.65 [0.5, 0.86]
  1 study · 341 participants
  Low

Mild clobetasol propionate cream regimen (10 to 30 g/day) vs standard clobetasol propionate cream regimen (40 g/day)

Mild clobetasol propionate cream regimen (10 to 30 g/day) showed no clear difference in disease control (healing of skin lesions) at day 21.… compared with standard clobetasol propionate cream regimen (40 g/day) (moderate certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 1 [0.97, 1.03]
  1 study · 312 participants
  Moderate

Mild clobetasol propionate cream regimen (10 to 30 g/day) vs standard clobetasol propionate cream regimen (40 g/day)

Mild clobetasol propionate cream regimen (10 to 30 g/day) showed no clear difference in mortality at 1 year compared with standard clobetasol propionate cream regimen (40 g/day) (low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 1 [0.75, 1.32]
  1 study · 312 participants
  Low

Mild clobetasol propionate cream regimen (10 to 30 g/day) vs standard clobetasol propionate cream regimen (40 g/day)

The review found no eligible studies for this question.

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Mild clobetasol propionate cream regimen (10 to 30 g/day) vs standard clobetasol propionate cream regimen (40 g/day)

Mild clobetasol propionate cream regimen (10 to 30 g/day) showed no clear difference in adverse events at 1 year compared with standard clobetasol propionate cream regimen (40 g/day) (low certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.94 [0.78, 1.14]
  1 study · 309 participants
  Low

Doxycycline vs prednisolone

Doxycycline leads to lower disease control at 6 weeks (unadjusted raw data) compared with prednisolone (high certainty).

• Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
  RR 0.81 [0.72, 0.92]
  1 study · 213 participants
  High

An intervention in which one's attention is on the experience of stress (feelings, thoughts, behavior) vs no intervention/wait list/placebo/no stress‐reduction intervention

• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  41 studies · 3645 participants
  Low
• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  19 studies · 1851 participants
  Low
• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 68 participants
  Very low

A combination of individual‐level interventions vs no intervention/wait list/placebo/no stress‐reduction intervention

• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  15 studies · 1003 participants
  Low
• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 574 participants
  Low
• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 88 participants
  Very low

An intervention in which one's attention is away from the experience of stress vs no intervention/wait list/placebo/no stress‐reduction intervention

• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  35 studies · 2366 participants
  Low
• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 427 participants
  Low
• Individual‐level interventions for reducing occupational stress in healthcare workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported