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Evidence found and GRADE certainty

4,860 questions · 64,864 findings · 4,913 reviews · Headline outcomes only

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No studies found 13,869 · 21.4%GRADE not reported 3,491 · 5.4%Very low 16,300 · 25.1%Low 17,338 · 26.7%Moderate 10,900 · 16.8%High 2,966 · 4.6%

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Mammography in combination with breast ultrasonography vs mammography alone

False‐negative rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography probably leads to lower false‐negative rate in women with dense breasts compared with mammography alone (moderate certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Biopsy rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography leads to higher biopsy rate in women with dense breasts compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental cancer detection for women with non‐dense breasts: cohort studies · breast cancer screening (non‐dense breasts)

Mammography in combination with breast ultrasonography probably leads to higher incremental cancer detection for women with non‐dense breasts: RCT compared with mammography alone (moderate certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Interval cancer · breast cancer screening (non‐dense breasts)

Mammography in combination with breast ultrasonography showed no clear difference in interval cancer compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐positive rate in women with non‐dense breasts · breast cancer screening (non‐dense breasts)

Mammography in combination with breast ultrasonography leads to higher false‐positive rate in women with non‐dense breasts compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐negative rate in women with non‐dense breasts · breast cancer screening (non‐dense breasts)

Mammography in combination with breast ultrasonography probably leads to lower false‐negative rate in women with non‐dense breasts compared with mammography alone (moderate certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Biopsy rate in women with non‐dense breasts · breast cancer screening (non‐dense breasts)

Mammography in combination with breast ultrasonography leads to higher biopsy rate in women with non‐dense breasts compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental cancer detection: cohort studies · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher incremental cancer detection: RCT compared with mammography alone (high certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental detection of invasive cancers · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in incremental detection of invasive cancers: RCT compared with mammography alone (low certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Interval cancer · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to lower interval cancer compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Lymph node status · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography probably leads to lower lymph node status compared with mammography alone (moderate certainty).

1 finding from 1 review

Hormonal therapy vs placebo or no intervention

Effect on later sexual function · symptomatic or early postmenopausal women1.
4 findings from 1 review
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Hormonal therapy vs placebo or no intervention

Effect on later sexual function · Postmenopausal women
5 findings from 1 review
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Application of heat vs application of cold

At least a clinically significant reduction in pain within 6 hours Reported in studies as: clinically improved or reduced pain,a or cessation of pain at end of treatmentb · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes at least a clinically significant reduction in pain within 6 hours… compared with application of cold (very low certainty).

1 finding from 1 review

Intervention not reported

Clinically significant reduction in pain · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cessation of pain at end of treatmenta · people stung accidentally by box jellyfish that do not cause Irukandji syndrome (Hawaiian box jellyfish; Carybdea alata) and healthy…
1 finding from 1 review