All‐cause mortality · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in mortality compared with placebo or usual care (moderate certainty).
1 finding from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
2 findings from 1 review
Caries susceptibility, enamel demineralisation, erosion, or microhardness · Permanent teeth or extracted human teeth with artificial lesions
The laboratory studies did not find increased susceptibility to caries or enamel demineralisation, but no firm conclusions can be drawn because of high risk of bias.
1 finding from 1 review
no estimate extracted
5 studies
GRADE not reported
Completion of dental treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
Acceptance of LA · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC + CT genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC + CT model: OR 0.73, 95% CI 0.19-2.87) in the Control group: Caries-free subgroup; certainty not graded.
4 findings from 1 review
Show 1 more finding
COVID-19 viral content of aerosol (when present) · Patients with suspected or confirmed COVID-19 infection
The review found no eligible studies for this question.
1 finding from 1 review
Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Clobetasol propionate 0.025% microspheres showed no clear difference in clinical resolution compared with clobetasol propionate 0.025% ointment; GRADE not reported.
1 finding from 1 review
Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with etch-and-rinse adhesive systems (in vitro)
Prior acid etching with etch-and-rinse adhesives did not significantly change microleakage after Er,Cr:YSGG preparation (RR 1.18, 95% CI 0.63-2.22; ungraded).
1 finding from 1 review
RR 1.18 [0.63, 2.22]
2 studies
GRADE not reported
Ozonisation vs No ozonisation / standard operatory
Outcome not reported · Dental healthcare providers (dentist, dental surgery assistant, dental hygienist, dental technologist, dental laboratory staff, dental…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Probing pocket depth · Adults with chronic periodontitis
Levofloxacin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
1 finding from 1 review
Number of visits to the dentist for repair of sealant or fluoride varnish application · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
1 finding from 1 review
All three included trials (Matarazzo 2008; Silva 2011; Xajigeorgiou 2006) reported adverse events in both MTZ + SRP and AMOX + MTZ + SRP groups (nausea, vomiting, diarrhoea, headache, metallic taste, irritability, mild…
3 studies · 84 participants
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between T allele vs C allele of AMELX rs6639060 and dental caries susceptibility (T vs C model: OR 1.08, 95% CI 0.63-1.85) in the Ethnicity: Caucasian subgroup; certainty not graded.
2 findings from 1 review
Oral health attitudes (1-7 scale) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with 24-month recall showed no clear difference in oral health attitudes (1-7 scale) compared with clinical examination with 6-month recall; GRADE not reported.
1 finding from 1 review
Adverse events · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.
1 finding from 1 review
Successful LA/painless treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
Salivary function impairment (buffering capacity, flow rate, oral pH) · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)
Reflux is associated with impaired salivary function (notably reduced buffering capacity) as a proposed pathophysiological mechanism, based on several ungraded studies.
1 finding from 1 review
Mixed/controversial salivary findings: reduced salivary buffering capacity supported in three studies (Correa, Holbrook, Filipi) with low oral pH and reduced flow as additional factors in GERD patients, but Meurman and Schroeder found no significant salivary abnormalities; no pooled estimate.
6 studies
GRADE not reported