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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Topical triamcinolone acetonide vs Topical tacrolimus

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes clinical resolution compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Vegetarian diet (any diet excluding all meat, poultry and fish) vs Nonvegetarian diet

Number of natural teeth (missing/present teeth, edentulousness, MT component of DMFT) · General population (children and adults) assessed for dental hard-tissue health

Evidence on the number of natural teeth was conflicting and could not be pooled (ungraded).

1 finding from 1 review
  • Vegetarian diet and its possible influence on dental health: A systematic literature review. 2020 All outcomes
    Multiple countries (mostly India; also Finland and other European countries, Brazil, Trinidad and Tobago); community and clinical settings
    Seven studies reported on the number of teeth with conflicting findings; meta-analysis was not possible due to inconsistent outcome definitions. One study found vegetarians had significantly more teeth; two found no…
    7 studies
    GRADE not reported

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Probing pocket depth · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Surgical removal (extraction) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth

Undesirable outcomes associated with removal (alveolar osteitis/postoperative infection, nerve injury, damage to adjacent teeth, bleeding, osteonecrosis, inflammation/infection) · Adolescents or adults with asymptomatic disease-free impacted wisdom teeth

The review found no eligible studies for this question.

1 finding from 1 review

Clinical examination with 24-month recall vs Clinical examination with 12-month recall

Total time (examination plus treatment) (minutes) · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk)

Clinical examination with 24-month recall showed no clear difference in total time (examination plus treatment) (minutes) compared with clinical examination with 12-month recall; GRADE not reported.

1 finding from 1 review

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Tooth bleaching (carbamide or hydrogen peroxide; home and/or in-office) vs No bleaching (untreated or pH-cycling control)

Caries susceptibility, enamel demineralisation, erosion, or microhardness · Permanent teeth / enamel specimens (in vitro)

Low-quality in vitro evidence suggests that bleaching of permanent teeth does not increase susceptibility to caries, demineralisation or erosion (ungraded); the clinical question could not be answered because only in vitro studies were available.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Australia, the pooled prevalence of primary-teeth caries in children was 28.5% (95% CI 20.3 to 38.5); certainty not graded.

1 finding from 1 review

AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.69, 95% CI 0.78-3.68) in the Ethnicity: Mixed subgroup; certainty not graded.

5 findings from 1 review
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Primary (complete) wound closure vs Secondary (partial) wound closure

Adverse effects (reactionary bleeding) · Adults with mandibular third molars requiring removal

It is very uncertain whether primary (complete) wound closure changes adverse effects (reactionary bleeding) compared with secondary (partial) wound closure (very low certainty).

1 finding from 1 review

Drain use vs No drain

Maximal mouth opening (interincisal distance) · Adults with mandibular third molars requiring removal

Surgical drain (tube or gauze) led to higher maximum mouth opening (mean) compared with no drain; GRADE not reported.

1 finding from 1 review